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    arhgap12b Rho GTPase activating protein 12b [ Danio rerio (zebrafish) ]

    Gene ID: 393848, updated on 17-Aug-2024

    Summary

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    Official Symbol
    arhgap12bprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 12bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1727
    See related
    Ensembl:ENSDARG00000026482 AllianceGenome:ZFIN:ZDB-GENE-040426-1727
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgap12; zgc:73239
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in retina and somite. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgap12b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (26622013..26725953)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (26530654..26634598)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440143 Neighboring gene potassium channel tetramerization domain containing 2 Neighboring gene hexosaminidase d Neighboring gene zinc finger E-box binding homeobox 1b Neighboring gene zinc finger protein 438

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data. Yin J, et al. BMC Genomics, 2010 Jan 20. PMID 20089164, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC73239

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 12; rho GTPase-activating protein 12b
    Names
    Rho GTPase activating protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200874.1 → NP_957168.1  rho GTPase-activating protein 12b

      See identical proteins and their annotated locations for NP_957168.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063321
      UniProtKB/TrEMBL
      Q6P4P5
      Related
      ENSDARP00000046958.3, ENSDART00000046959.5
      Conserved Domains (6) summary
      cd12070
      Location:17 → 76
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:624 → 810
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:435 → 546
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:449 → 544
      PH; PH domain
      pfam00397
      Location:271 → 297
      WW; WW domain
      pfam16618
      Location:73 → 267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      26622013..26725953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480044.1 → XP_021335719.1  rho GTPase-activating protein 12 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QE56
      Conserved Domains (3) summary
      cd12070
      Location:17 → 76
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      pfam00397
      Location:271 → 297
      WW; WW domain
      pfam16618
      Location:73 → 267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    2. XM_021480040.1 → XP_021335715.1  rho GTPase-activating protein 12 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QME4
      Conserved Domains (5) summary
      cd12070
      Location:17 → 76
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:689 → 875
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:459 → 611
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:271 → 297
      WW; WW domain
      pfam16618
      Location:73 → 267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    3. XM_021480041.1 → XP_021335716.1  rho GTPase-activating protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QIL2
      Conserved Domains (5) summary
      cd12070
      Location:17 → 76
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:688 → 874
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:459 → 611
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:271 → 297
      WW; WW domain
      pfam16618
      Location:73 → 267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    4. XM_009306595.3 → XP_009304870.1  rho GTPase-activating protein 12 isoform X4

      UniProtKB/TrEMBL
      A0A0R4IKK1, A0A8M3BE39
      Related
      ENSDARP00000134177.2, ENSDART00000158440.2
      Conserved Domains (6) summary
      cd12070
      Location:17 → 76
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:648 → 834
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:459 → 570
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:473 → 568
      PH; PH domain
      pfam00397
      Location:271 → 297
      WW; WW domain
      pfam16618
      Location:73 → 267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    5. XM_021480042.1 → XP_021335717.1  rho GTPase-activating protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PW53
      Conserved Domains (5) summary
      cd12070
      Location:17 → 76
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:665 → 851
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:435 → 587
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:271 → 297
      WW; WW domain
      pfam16618
      Location:73 → 267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    6. XM_021480043.1 → XP_021335718.1  rho GTPase-activating protein 12 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q893
      Conserved Domains (4) summary
      cd04403
      Location:471 → 657
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:241 → 393
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:53 → 79
      WW; WW domain
      pfam16618
      Location:9 → 49
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394846.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      75425..182061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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