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    nlgn4xa neuroligin 4 X-linked a [ Danio rerio (zebrafish) ]

    Gene ID: 561122, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nlgn4xaprovided by ZNC
    Official Full Name
    neuroligin 4 X-linked aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100309-2
    See related
    Ensembl:ENSDARG00000079455 AllianceGenome:ZFIN:ZDB-GENE-100309-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nlgn4a; nlgn4b
    Summary
    Predicted to enable neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be active in cell surface and postsynaptic specialization membrane. Is expressed in several structures, including brain; eye; gonad; spinal cord interneuron; and swim bladder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including NLGN4X (neuroligin 4 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See nlgn4xa in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (32521563..32693355)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (31788979..31959911)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490019 Neighboring gene uncharacterized LOC137495266 Neighboring gene uncharacterized LOC562564 Neighboring gene protein kinase X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential expression of neuroligin genes in the nervous system of zebrafish. Davey C, et al. Dev Dyn, 2010 Feb. PMID 20063411, Free PMC Article
    2. Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Gonçalves C, et al. Genes Brain Behav, 2022 Jun. PMID 35524578, Free PMC Article
    3. Characterization of the neuroligin gene family expression and evolution in zebrafish. Rissone A, et al. Dev Dyn, 2010 Feb. PMID 20034102
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic specialization membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neuroligin 4 X-linked a
    Names
    neuroligin 4a
    neuroligin 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166331.1 → NP_001159803.1  neuroligin 4 X-linked a

      See identical proteins and their annotated locations for NP_001159803.1

      Status: PROVISIONAL

      Source sequence(s)
      GQ892839
      UniProtKB/TrEMBL
      D0EVX4
      Conserved Domains (2) summary
      COG0657
      Location:148 → 263
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:37 → 587
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      32521563..32693355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475240.2 → XP_021330915.1  neuroligin 4 X-linked a isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBU0
      Related
      ENSDARP00000103677.3, ENSDART00000113818.4
      Conserved Domains (1) summary
      pfam00135
      Location:43 → 605
      COesterase; Carboxylesterase family

    2. XM_068219896.1 → XP_068075997.1  neuroligin 4 X-linked a isoform X2

      Related
      ENSDARP00000110247.1, ENSDART00000128317.3

    3. XM_009292174.4 → XP_009290449.1  neuroligin 4 X-linked a isoform X3

      UniProtKB/TrEMBL
      A0A8M3AIZ9, R4GE10
      Related
      ENSDARP00000126721.1, ENSDART00000152580.3
      Conserved Domains (2) summary
      COG0657
      Location:148 → 263
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:39 → 587
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version

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