myo1eb myosin IEb [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myo1ebprovided by ZNC
Official Full Name: myosin IEbprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1347
See related: Ensembl:ENSDARG00000009133 AllianceGenome:ZFIN:ZDB-GENE-040426-1347
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64042
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within glomerular filtration and glomerulus development. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in several structures, including EVL; ectoderm; epidermis; peripheral olfactory organ; and pharynx. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (38201840..38238902)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (38251808..38288870)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glomerular filtration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glomerulus development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin IEb

Names: myosin IE, b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200636.1 → NP_956930.1 myosin IEb

See identical proteins and their annotated locations for NP_956930.1

Status: PROVISIONAL

Source sequence(s)

BC057426

UniProtKB/TrEMBL

Q6PFT4

Related

ENSDARP00000044970.5, ENSDART00000044971.6

Conserved Domains (4) summary

cd11827
Location:1043 → 1095

SH3_MyoIe_If_like; Src homology 3 domain of Myosins Ie, If, and similar proteins

smart00242
Location:12 → 690

MYSc; Myosin. Large ATPases

cd01378
Location:31 → 677

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:717 → 902

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding