pdcd4b programmed cell death 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdcd4bprovided by ZNC
Official Full Name: programmed cell death 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9847
See related: Ensembl:ENSDARG00000041022 AllianceGenome:ZFIN:ZDB-GENE-030131-9847
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb45; pdcd4; sb:cb45; wu:fc84b08
Summary: Acts upstream of or within atrioventricular valve development. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in atrioventricular canal; eye; hindbrain; segmental plate; and solid lens vesicle. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (29658983..29689969, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (29709788..29740803, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4
Title: miR-21 represses Pdcd4 during cardiac valvulogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fc84b08.x1 (e-PCR)
- UniSTS:188327

fj32h08.y1 (e-PCR)
- UniSTS:199089

fc55f12 (e-PCR)
- UniSTS:189364

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular valve development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrioventricular valve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: programmed cell death protein 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.