lpcat2 lysophosphatidylcholine acyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lpcat2provided by ZNC
Official Full Name: lysophosphatidylcholine acyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-229
See related: Ensembl:ENSDARG00000053010 AllianceGenome:ZFIN:ZDB-GENE-050522-229
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: aytl1; zgc:112165
Summary: Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and 1-alkylglycerophosphocholine O-acetyltransferase activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human LPCAT2 (lysophosphatidylcholine acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (35386052..35408384, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (35114575..35136890, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables plasmalogen synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophosphatidylcholine acyltransferase 2

Names: 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 2; LPCAT-2; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase like 1; lyso-PAF acetyltransferase; lysoPAFAT; lysoPC acyltransferase 2

NP_001018492.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_005169036.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020656.1 → NP_001018492.1 lysophosphatidylcholine acyltransferase 2

See identical proteins and their annotated locations for NP_001018492.1

Status: PROVISIONAL

Source sequence(s)

BC095679

UniProtKB/Swiss-Prot

Q502J0

Related

ENSDARP00000069449.3, ENSDART00000074963.4

Conserved Domains (5) summary

cd07991
Location:98 → 309

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:49 → 297

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

cd00051
Location:418 → 473

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:415 → 473

EF-hand_7; EF-hand domain pair

cl08302
Location:316 → 406

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

35386052..35408384 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168979.4 → XP_005169036.1 lysophosphatidylcholine acyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0A8M2BG99, F1Q8S6

Related

ENSDARP00000111397.1, ENSDART00000128334.4

Conserved Domains (5) summary

cd07991
Location:98 → 309

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:49 → 297

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

cd00051
Location:418 → 473

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:415 → 473

EF-hand_7; EF-hand domain pair

cl08302
Location:316 → 406

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...