park7 parkinson protein 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: park7provided by ZNC
Official Full Name: parkinson protein 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-5
See related: Ensembl:ENSDARG00000116835 AllianceGenome:ZFIN:ZDB-GENE-041010-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dj1; zgc:103725
Summary: Predicted to enable several functions, including glyoxalase (glycolic acid-forming) activity; oxidoreductase activity, acting on peroxide as acceptor; and protein homodimerization activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; retina homeostasis; and swimming behavior. Predicted to be located in endoplasmic reticulum; membrane raft; and plasma membrane. Predicted to be active in mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; digestive system; male organism; musculature system; and nervous system. Used to study Parkinson's disease and retinal degeneration. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (41459837..41474162)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (40847607..40861932)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish.
Title: Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish.
Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.
Title: Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.
Label-free mass spectrometry was employed to identify altered protein expression in the DJ-1 null brain of early adult animals.
Title: Dysregulation in the Brain Protein Profile of Zebrafish Lacking the Parkinson's Disease-Related Protein DJ-1.
by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2.
Title: Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo.
Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
Title: Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
Title: Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables glyoxalase (glycolic acid-forming) activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein deglycase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein deglycase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in guanine deglycation	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine deglycation, glyoxal removal	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine deglycation, methylglyoxal removal	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in methylglyoxal metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidative phosphorylation uncoupler activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Parkinson disease protein 7 homolog

Names: DJ-1 protein; maillard deglycase; parkinson disease (autosomal recessive, early onset) 7; parkinson disease protein 7 homolog; parkinsonism-associated deglycase; protein DJ-1; protein DJ-1zDJ-1; protein deglycase DJ-1zDJ-1; protein/nucleic acid deglycase DJ-1; zDJ-1

NP_001005938.1

EC 3.5.1.124

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005938.1 → NP_001005938.1 Parkinson disease protein 7 homolog

See identical proteins and their annotated locations for NP_001005938.1

Status: PROVISIONAL

Source sequence(s)

BC083475

UniProtKB/Swiss-Prot

Q5XJ36

Related

ENSDARP00000150435.1, ENSDART00000182285.1

Conserved Domains (2) summary

cd03135
Location:6 → 172

GATase1_DJ-1; Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1

TIGR01383
Location:5 → 184

not_thiJ; DJ-1 family protein