selenol selenoprotein L [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenolprovided by ZNC
Official Full Name: selenoprotein Lprovided by ZNC
Primary source: ZFIN:ZDB-GENE-141212-269
See related: Ensembl:ENSDARG00000088444 AllianceGenome:ZFIN:ZDB-GENE-141212-269
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sell
Summary: The protein encoded by this gene belongs to a subfamily of selenoprotein L (SelL), within a superfamily of thioredoxin (Trx). SelL is unusual in that it has restricted phylogenetic distribution in aquatic organisms; in vertebrates, it is found only in fish, but not in mammals, birds or amphibians. SelL proteins possess a thioredoxin-like fold, where the UxxU (U for selenocysteine) motif replaces the catalytic CxxC (C for cysteine) motif in thioredoxins, suggesting a redox function for this protein family. Unlike majority of selenoproteins, selenoprotein L contains two selenocysteine (Sec) residues encoded by UGA codons, that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene uses a single SECIS element to insert both Sec residues. [provided by RefSeq, Aug 2017]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (3941986..3953638, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (4078267..4089231)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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General protein information

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Preferred Names: selenoprotein L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190382.2 → NP_001177311.1 selenoprotein L

Status: REVIEWED

Source sequence(s)

CU929133

UniProtKB/TrEMBL

A0A8M1NX36

Related

ENSDARP00000157551.1, ENSDART00000124197.3

Conserved Domains (1) summary

cl00388
Location:130 → 279

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold