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    eif3ea eukaryotic translation initiation factor 3, subunit E, a [ Danio rerio (zebrafish) ]

    Gene ID: 325102, updated on 2-Nov-2024

    Summary

    Official Symbol
    eif3eaprovided by ZNC
    Official Full Name
    eukaryotic translation initiation factor 3, subunit E, aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3827
    See related
    Ensembl:ENSDARG00000090697 AllianceGenome:ZFIN:ZDB-GENE-030131-3827
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eif3s6; eif3s6a; fc55e01; eIF3-p48; zgc:63821; wu:fc55e01
    Summary
    Predicted to contribute to translation initiation factor activity. Acts upstream of or within camera-type eye development; embryonic viscerocranium morphogenesis; and pigmentation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Predicted to be active in nucleus. Is expressed in ceratobranchial cartilage; eye; female organism; and gut. Orthologous to human EIF3E (eukaryotic translation initiation factor 3 subunit E). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See eif3ea in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (38556846..38629126, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (38606814..38679094, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene CD83 molecule Neighboring gene R-spondin 2 Neighboring gene ER membrane protein complex subunit 2 Neighboring gene uncharacterized LOC137487849

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC63821

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pigmentation IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of eukaryotic translation initiation factor 3 complex, eIF3e IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit E-A
    Names
    eukaryotic translation initiation factor 3, subunit 6a
    int6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200839.1NP_957133.1  eukaryotic translation initiation factor 3 subunit E-A

      See identical proteins and their annotated locations for NP_957133.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061454
      UniProtKB/Swiss-Prot
      Q1LUA7, Q1LUA8, Q6DRI1, Q6P7X8, Q6TH16
      Related
      ENSDARP00000106853.2, ENSDART00000126705.4
      Conserved Domains (2) summary
      pfam01399
      Location:291395
      PCI; PCI domain
      pfam09440
      Location:5138
      eIF3_N; eIF3 subunit 6 N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      38556846..38629126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394970.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      292488..364505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)