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    frmd6 FERM domain containing 6 [ Danio rerio (zebrafish) ]

    Gene ID: 321937, updated on 2-Nov-2024

    Summary

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    Official Symbol
    frmd6provided by ZNC
    Official Full Name
    FERM domain containing 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-354
    See related
    Ensembl:ENSDARG00000002332 AllianceGenome:ZFIN:ZDB-GENE-050522-354
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb38g08; zgc:110114
    Summary
    Predicted to be involved in positive regulation of hippo signaling. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasmic side of apical plasma membrane. Orthologous to human FRMD6 (FERM domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See frmd6 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36958086..36995448)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36832196..36869558)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 9 Neighboring gene thioredoxin-related transmembrane protein 1 Neighboring gene uncharacterized LOC137487339 Neighboring gene estrogen receptor 2b Neighboring gene spectrin repeat containing, nuclear envelope 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Disruption of Trim9 function abrogates macrophage motility in vivo. Tokarz DA, et al. J Leukoc Biol, 2017 Dec. PMID 29021367, Free PMC Article
    2. Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Mateus R, et al. Development, 2015 Aug 15. PMID 26209644, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020816.1 → NP_001018652.1  FERM domain-containing protein 6

      See identical proteins and their annotated locations for NP_001018652.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095176
      UniProtKB/TrEMBL
      Q503U6
      Related
      ENSDARP00000024425.8, ENSDART00000024386.11
      Conserved Domains (4) summary
      smart00295
      Location:20 → 215
      B41; Band 4.1 homologues
      cd13185
      Location:219 → 327
      FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
      pfam00373
      Location:115 → 226
      FERM_M; FERM central domain
      pfam09379
      Location:20 → 82
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      36958086..36995448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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