ncaph non-SMC condensin I complex, subunit H [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ncaphprovided by ZNC
Official Full Name: non-SMC condensin I complex, subunit Hprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-652
See related: Ensembl:ENSDARG00000061468 AllianceGenome:ZFIN:ZDB-GENE-070112-652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158618; si:dkeyp-86b9.4
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within mitotic sister chromatid segregation. Predicted to be located in chromosome and cytoplasm. Predicted to be part of condensin complex. Is expressed in brain; ciliary marginal zone; optic cup; and spinal cord. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPH (non-SMC condensin I complex subunit H). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (28259654..28270941)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (27659501..27670788)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the interaction partners CAP-H and CAP-D2 causes cytoplasmic mislocalization of CAP-G throughout mitosis.
Title: Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina.

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General gene information

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Markers

fc69h06.x1 (e-PCR)
- UniSTS:188232

fa09d09.r1 (e-PCR)
- UniSTS:189565

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic chromosome condensation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic sister chromatid segregation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mitotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IEA Inferred from Electronic Annotation more info
part_of condensin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: condensin complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.