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    kpna4 karyopherin alpha 4 (importin alpha 3) [ Danio rerio (zebrafish) ]

    Gene ID: 327373, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kpna4provided by ZNC
    Official Full Name
    karyopherin alpha 4 (importin alpha 3)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5584
    See related
    Ensembl:ENSDARG00000023190 AllianceGenome:ZFIN:ZDB-GENE-030131-5584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    impa3; wu:fa56d07; wu:fa66g10; wu:fe14c04; wu:fi04h11; wu:fi19b05
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within lens development in camera-type eye. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kpna4 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1218675..1622464, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1631599..1657545, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene latexin Neighboring gene major facilitator superfamily domain containing 1 Neighboring gene si:dkeyp-97b10.3 Neighboring gene schwannomin interacting protein 1 Neighboring gene interleukin 12a Neighboring gene chromosome 15 C3orf80 homolog Neighboring gene intraflagellar transport 80 homolog (Chlamydomonas) Neighboring gene microRNA 15c Neighboring gene microRNA 16a Neighboring gene structural maintenance of chromosomes 4 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene tripartite motif containing 59 Neighboring gene nanor Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1Lb Neighboring gene NMD3 ribosome export adaptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. KPNA4 is involved in cataract formation via the nuclear import of p53. Ping X, et al. Gene, 2021 Jun 20. PMID 33798680
    2. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Schüttler A, et al. Toxicol Sci, 2017 Jun 1. PMID 28329862, Free PMC Article
    3. Identification of zygotic genes expressed at the midblastula transition in zebrafish. O'Boyle S, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17490614
    4. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201305.1 → NP_958462.1  importin subunit alpha-3

      See identical proteins and their annotated locations for NP_958462.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045358
      UniProtKB/TrEMBL
      Q7ZVY9
      Related
      ENSDARP00000039386.8, ENSDART00000034456.10
      Conserved Domains (4) summary
      COG5064
      Location:2 → 520
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:108 → 229
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:10 → 93
      IBB; Importin beta binding domain
      sd00043
      Location:109 → 142
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      1218675..1622464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213472.1 → XP_068069573.1  importin subunit alpha-3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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