U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tlk2 tousled-like kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 407732, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tlk2provided by ZNC
    Official Full Name
    tousled-like kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060623-36
    See related
    Ensembl:ENSDARG00000010779 AllianceGenome:ZFIN:ZDB-GENE-060623-36
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fi16h09; wu:fi30g12; zgc:136697
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm; cytoskeleton; and nucleoplasm. Predicted to be active in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tlk2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (19685833..19717932)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (19536060..19568192)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene integrin beta 3a Neighboring gene methyltransferase 2A, methylcytidine Neighboring gene mannose receptor, C-type 2 Neighboring gene Rho family GTPase 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0137, MGC136697, MGC173515

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase tousled-like 2
    Names
    pKU-alpha protein kinase
    NP_001103887.1
    XP_021325815.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110417.1 → NP_001103887.1  serine/threonine-protein kinase tousled-like 2

      See identical proteins and their annotated locations for NP_001103887.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154737
      UniProtKB/Swiss-Prot
      A8WGJ6, Q1ECX4, Q90ZY7
      UniProtKB/TrEMBL
      A0A2R8QUZ6
      Related
      ENSDARP00000003372.7, ENSDART00000006490.9
      Conserved Domains (2) summary
      smart00220
      Location:399 → 666
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:381 → 684
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      19685833..19717932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470140.2 → XP_021325815.1  serine/threonine-protein kinase tousled-like 2 isoform X1

      UniProtKB/Swiss-Prot
      A8WGJ6, Q1ECX4, Q90ZY7
      UniProtKB/TrEMBL
      A0A8M9PXE3
      Conserved Domains (1) summary
      cl21453
      Location:380 → 683
      PKc_like; Protein Kinases, catalytic domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394527.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      156813..187257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1ECX4.2 GenPept UniProtKB/Swiss-Prot:Q1ECX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools