bdnf brain-derived neurotrophic factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bdnfprovided by ZNC
Official Full Name: brain-derived neurotrophic factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000412-1
See related: Ensembl:ENSDARG00000018817 AllianceGenome:ZFIN:ZDB-GENE-000412-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Acts upstream of or within multicellular organismal response to stress and nervous system development. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including blastoderm; digestive system; nervous system; oral region; and pericardial region. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (31924983..31941670, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (31653838..31670520, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish.
Title: bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish.
DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish.
Title: DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish.
Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear.
Title: Expression and Localization of BDNF/TrkB System in the Zebrafish Inner Ear.
Zebrafish brain possesses intense neurogenesis that can be correlated with high regenerative properties. Recently, the zebrafish has been proposed as a valid experimental paradigm to study the association of BDNF and neural repair after traumatic brain injury.[review]
Title: BDNF, Brain, and Regeneration: Insights from Zebrafish.
BDNF is involved in the gonadal function of adult zebrafish, and mainly in the adult ovary.
Title: Morpho-Functional Features of the Gonads of Danio rerio: the Role of Brain-Derived Neurotrophic Factor.
One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks.findings demonstrate that TOR activation in old animals occurs in the early phase of consolidation, and follows a pattern identical to that of BDNF expression.
Title: Effects of learning on mTOR pathway gene expression in the brain of zebrafish (Danio rerio) of different ages.
These results suggest an involvement of the BDNF/TrkB system in the regulation of food intake and energy balance in zebrafish, as in mammals
Title: Morphological differences in adipose tissue and changes in BDNF/Trkb expression in brain and gut of a diet induced obese zebrafish model.
BDNF-TrkB influences the expression level of components of chemokine signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Title: BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors.
Light regulates the expression of the BDNF/TrkB2 system in the adult zebrafish retina.
Title: Light regulates the expression of the BDNF/TrkB system in the adult zebrafish retina.
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Title: Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IEP Inferred from Expression Pattern more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within presynapse assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: brain-derived neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308648.1 → NP_001295577.1 brain-derived neurotrophic factor isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL935207, CU459028

UniProtKB/TrEMBL

A0A8M1P735

Related

ENSDARP00000069872.3, ENSDART00000075389.4

Conserved Domains (1) summary

smart00140
Location:164 → 271

NGF; Nerve growth factor (NGF or beta-NGF)
NM_001308649.1 → NP_001295578.1 brain-derived neurotrophic factor isoform 2 precursor

See identical proteins and their annotated locations for NP_001295578.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

AL935207, CU459028

UniProtKB/TrEMBL

A0A2R8QDP6, F6PAL5, Q6NZ01

Related

ENSDARP00000152925.1, ENSDART00000180929.1

Conserved Domains (1) summary

smart00140
Location:156 → 263

NGF; Nerve growth factor (NGF or beta-NGF)
NM_131595.2 → NP_571670.2 brain-derived neurotrophic factor isoform 2 precursor

See identical proteins and their annotated locations for NP_571670.2

Status: VALIDATED

Description

Transcript Variant: This variant uses an alternate 5' exon which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

BC058301

UniProtKB/TrEMBL

A0A2R8QDP6, F6PAL5, Q6NZ01

Related

ENSDARP00000010990.5, ENSDART00000014843.6

Conserved Domains (1) summary

smart00140
Location:156 → 263

NGF; Nerve growth factor (NGF or beta-NGF)