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    lgals3a lectin, galactoside binding soluble 3a [ Danio rerio (zebrafish) ]

    Gene ID: 557373, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lgals3aprovided by ZNC
    Official Full Name
    lectin, galactoside binding soluble 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7667
    See related
    Ensembl:ENSDARG00000077850 AllianceGenome:ZFIN:ZDB-GENE-030131-7667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lgals3; fb13c09; fk60g08; si:ch211-67f24.5
    Summary
    Predicted to enable IgE binding activity and laminin binding activity. Predicted to be involved in several processes, including leukocyte chemotaxis; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of calcium ion import. Predicted to act upstream of or within RNA splicing; innate immune response; and mRNA processing. Predicted to be located in extracellular region. Predicted to be part of spliceosomal complex. Predicted to be active in several cellular components, including extracellular space; immunological synapse; and nucleus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See lgals3a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36568635..36582348, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (36442803..36456562, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene deubiquitinase DESI2 Neighboring gene synaptojanin 2 binding protein Neighboring gene glia maturation factor, beta Neighboring gene cornichon family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Correlated expression of retrocopies and parental genes in zebrafish. Zhong Z, et al. Mol Genet Genomics, 2016 Apr. PMID 26561303
    2. npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Wiweger M, et al. Front Cell Neurosci, 2021. PMID 33986646, Free PMC Article
    3. CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. Keatinge M, et al. PLoS Genet, 2021 Apr. PMID 33914736, Free PMC Article
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables IgE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IgE binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables disaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in eosinophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of calcium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in immunological synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galectin-3
    Names
    lectin, galactoside-binding, soluble, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386796.1 → NP_001373725.1  galectin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX927407
      UniProtKB/TrEMBL
      A0A8N7UTJ9
      Related
      ENSDARP00000100661.3, ENSDART00000113204.4
      Conserved Domains (2) summary
      smart00908
      Location:246 → 362
      Gal-bind_lectin; Galactoside-binding lectin
      PRK07764
      Location:11 → 158
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    2. NM_001386797.1 → NP_001373726.1  galectin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX927407
      UniProtKB/TrEMBL
      A0A8M2B3V2
      Conserved Domains (1) summary
      PRK07764
      Location:26 → 241
      PRK07764; DNA polymerase III subunits gamma and tau; Validated

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      36568635..36582348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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