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    ZNF25 zinc finger protein 25 [ Homo sapiens (human) ]

    Gene ID: 219749, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF25provided by HGNC
    Official Full Name
    zinc finger protein 25provided by HGNC
    Primary source
    HGNC:HGNC:13043
    See related
    Ensembl:ENSG00000175395 MIM:194528; AllianceGenome:HGNC:13043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Zfp9; KOX19
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 11.8), adrenal (RPKM 6.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    10p11.21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (37949573..37976647, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (37993572..38020648, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38238501..38265575, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 37C, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:38186151-38186679 Neighboring gene zinc finger protein 33C, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3272 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:38274009-38274157 Neighboring gene ZNF25 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3273 Neighboring gene zinc finger protein 33A Neighboring gene RNA, U6 small nuclear 795, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells. Twine NA, et al. BMC Genomics, 2016 Nov 4. PMID 27814695, Free PMC Article
    2. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10q. Guy J, et al. Hum Mol Genet, 2000 Aug 12. PMID 10942432
    3. A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Rousseau-Merck MF, et al. Genomics, 1992 Jul. PMID 1639412
    4. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy J, et al. Genome Res, 2003 Feb. PMID 12566394, Free PMC Article
    5. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study shows that the uncharacterized transcription factor, ZNF25, is associated with differentiation of hMSC to osteoblasts.
      Title: Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31890, DKFZp564C206

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 25
    Names
    zinc finger protein 25 (KOX 19)
    zinc finger protein KOX19

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329647.2 → NP_001316576.1  zinc finger protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AL117337
      Conserved Domains (5) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:148 → 457
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:248 → 273
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001329648.2 → NP_001316577.1  zinc finger protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes isoform a, as do variants 1 and 3.
      Source sequence(s)
      AL117337
      Conserved Domains (5) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:148 → 457
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:248 → 273
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001329649.2 → NP_001316578.1  zinc finger protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform a, as do variants 1 and 2.
      Source sequence(s)
      AL117337, DA306585
      Conserved Domains (5) summary
      smart00349
      Location:12 → 72
      KRAB; krueppel associated box
      COG5048
      Location:148 → 457
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:248 → 273
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001329650.2 → NP_001316579.1  zinc finger protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform b, as do variants 4, 6, 7, 8, and 9.
      Source sequence(s)
      AL117337
      Consensus CDS
      CCDS7195.1
      UniProtKB/Swiss-Prot
      A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:144 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:244 → 269
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001329651.2 → NP_001316580.1  zinc finger protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes isoform b, as do variants 4, 5, 7, 8, and 9.
      Source sequence(s)
      AL117337
      Consensus CDS
      CCDS7195.1
      UniProtKB/Swiss-Prot
      A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:144 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:244 → 269
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001329652.2 → NP_001316581.1  zinc finger protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) encodes isoform b, as do variants 4, 5, 6, 8, and 9.
      Source sequence(s)
      AL117337
      Consensus CDS
      CCDS7195.1
      UniProtKB/Swiss-Prot
      A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:144 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:244 → 269
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001329653.2 → NP_001316582.1  zinc finger protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) encodes isoform b, as do variants 4, 5, 6, 7, and 9.
      Source sequence(s)
      AL117337
      Consensus CDS
      CCDS7195.1
      UniProtKB/Swiss-Prot
      A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:144 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:244 → 269
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001329654.2 → NP_001316583.1  zinc finger protein 25 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) encodes isoform b, as do variants 4-8.
      Source sequence(s)
      AL117337, DA113590
      Consensus CDS
      CCDS7195.1
      UniProtKB/Swiss-Prot
      A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:144 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:244 → 269
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001329655.2 → NP_001316584.1  zinc finger protein 25 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL117337, DA320329

    10. NM_001329656.2 → NP_001316585.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) encodes isoform d, as do variants 11-19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    11. NM_001329657.2 → NP_001316586.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes isoform d, as do variants 11 and 13-9.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    12. NM_001329658.2 → NP_001316587.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) encodes isoform d, as do variants 11-12 and 14-19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    13. NM_001329659.2 → NP_001316588.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) encodes isoform d, as do variants 11-13 and 15-19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    14. NM_001329660.2 → NP_001316589.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) encodes isoform d, as do variants 11-14 and 16-19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    15. NM_001329661.2 → NP_001316590.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) encodes isoform d, as do variants 11-15 and 17-19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    16. NM_001329662.2 → NP_001316591.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) encodes isoform d, as do variants 11-16 and 18-19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    17. NM_001329663.2 → NP_001316592.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) encodes isoform d, as do variants 11-17 and 19.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    18. NM_001329664.2 → NP_001316593.1  zinc finger protein 25 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) encodes isoform d, as do variants 11-18.
      Source sequence(s)
      AL117337
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:108 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 244
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:208 → 233
      zf-H2C2_2; Zinc-finger double domain

    19. NM_145011.4 → NP_659448.1  zinc finger protein 25 isoform b

      See identical proteins and their annotated locations for NP_659448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform b, as do variants 5-9.
      Source sequence(s)
      AL117337, BP229986
      Consensus CDS
      CCDS7195.1
      UniProtKB/Swiss-Prot
      A9Z1X5, P17030, Q8IYE3, Q8NDD6, Q96MU2
      Related
      ENSP00000302222.7, ENST00000302609.8
      Conserved Domains (5) summary
      smart00349
      Location:8 → 68
      KRAB; krueppel associated box
      COG5048
      Location:144 → 453
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:260 → 280
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:8 → 47
      KRAB; KRAB box
      pfam13465
      Location:244 → 269
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_138062.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    2. NR_138063.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    3. NR_138064.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    4. NR_138065.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    5. NR_138066.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    6. NR_138067.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    7. NR_138068.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337

    8. NR_138069.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337, DB042775

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      37949573..37976647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424716.1 → XP_047280672.1  zinc finger protein 25 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      37993572..38020648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365011.1 → XP_054220986.1  zinc finger protein 25 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17030.2 GenPept UniProtKB/Swiss-Prot:P17030

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Molecular Biology Databases
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    Miscellaneous