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    BMPR2 bone morphogenetic protein receptor type 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 407127, updated on 4-Oct-2024

    Summary

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    Official Symbol
    BMPR2provided by VGNC
    Official Full Name
    bone morphogenetic protein receptor type 2provided by VGNC
    Primary source
    VGNC:VGNC:26526
    See related
    Ensembl:ENSBTAG00000006420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    bmprii
    Orthologs
    human mouse all
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    Genomic context

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    See BMPR2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (90864689..91017391)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD11B Neighboring gene small nucleolar RNA SNORD11 Neighboring gene NOP58 ribonucleoprotein Neighboring gene family with sequence similarity 117 member B Neighboring gene islet cell autoantigen 1 like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways. Liu C, et al. Cell Physiol Biochem, 2018. PMID 29587293
    2. The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency. Workman A, et al. J Virol, 2018 Apr 1. PMID 29321317, Free PMC Article
    3. MicroRNA 17-92 cluster regulates proliferation and differentiation of bovine granulosa cells by targeting PTEN and BMPR2 genes. Andreas E, et al. Cell Tissue Res, 2016 Oct. PMID 27221279
    4. Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia. Yu H, et al. Am J Physiol Lung Cell Mol Physiol, 2019 Nov 1. PMID 31389735, Free PMC Article
    5. Single nucleotide polymorphisms in the bovine genome are associated with the number of oocytes collected during ovum pick up. Santos-Biase WK, et al. Anim Reprod Sci, 2012 Oct. PMID 22959639

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in pulmonary artery superoxide and its potential regulation of contractile phenotype proteins.
      Title: Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia.
    2. Inhibition of BMPR2 resulted in increased expression of ALK4 and decreased expression of PTX3, HAS2 and PTGS2.
      Title: Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways.
    3. These findings are important because Wnt, BMPR2, and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.
      Title: The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency.
    4. the miR-17-92 cluster is involved in granulosa cell proliferation and differentiation by coordinately targeting the PTEN and BMPR2 genes.
      Title: MicroRNA 17-92 cluster regulates proliferation and differentiation of bovine granulosa cells by targeting PTEN and BMPR2 genes.
    5. Genetic variability is an important component of the number of antral follicles in the bovine ovary.
      Title: Single nucleotide polymorphisms in the bovine genome are associated with the number of oocytes collected during ovum pick up.
    6. Stimulation of BMPRII promotes normal pulmonary artery endothelial cell function by activating eNOS.
      Title: Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transforming growth factor beta receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bone morphogenetic protein receptor type-2
    Names
    bone morphogenetic protein receptor, type II (serine/threonine kinase)
    NP_001291214.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304285.2 → NP_001291214.1  bone morphogenetic protein receptor type-2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      A0A3Q1LP90
      Related
      ENSBTAP00000058820.1, ENSBTAT00000073964.1
      Conserved Domains (3) summary
      smart00220
      Location:204 → 495
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14054
      Location:207 → 504
      STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
      pfam01064
      Location:60 → 131
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      90864689..91017391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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