brpf1 bromodomain and PHD finger containing, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: brpf1provided by ZNC
Official Full Name: bromodomain and PHD finger containing, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-731
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-731
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55530
Summary: Enables histone binding activity. Acts upstream of or within anterior/posterior pattern specification. Located in chromatin. Is expressed in brain; digestive system; epithelium; head; and olfactory pit. Orthologous to human BRPF1 (bromodomain and PHD finger containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (54135642..54170774)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (54034356..54079190)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data conclude that Brpf1, coordinated by its particular set of domains, acts by multiple mechanisms to mediate Moz-dependent histone acetylation and to mark Hox genes for maintained expression throughout vertebrate development.
Title: The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity.

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General gene information

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Markers

fk85f01.x1 (e-PCR)
- UniSTS:201629

fl04h09.x1 (e-PCR)
- UniSTS:201895

G45134 (e-PCR)
- UniSTS:105936

fi34h01.x1 (e-PCR)
- UniSTS:197352

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables histone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peregrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201016.1 → NP_957310.1 peregrin

See identical proteins and their annotated locations for NP_957310.1

Status: PROVISIONAL

Source sequence(s)

BC044418

UniProtKB/TrEMBL

Q803M2

Conserved Domains (4) summary

cd15676
Location:300 → 361

PHD_BRPF1; PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

cd15701
Location:363 → 483

ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

pfam10513
Location:124 → 288

EPL1; Enhancer of polycomb-like

cl02556
Location:678 → 775

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.