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    mtfmt mitochondrial methionyl-tRNA formyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 556680, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mtfmtprovided by ZNC
    Official Full Name
    mitochondrial methionyl-tRNA formyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-120
    See related
    Ensembl:ENSDARG00000005448 AllianceGenome:ZFIN:ZDB-GENE-060929-120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mtmft; zgc:152651
    Summary
    Predicted to enable methionyl-tRNA formyltransferase activity. Predicted to be involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Predicted to act upstream of or within translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mtfmt in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (52753073..52761572)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (52478003..52486502)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene transcription factor 12 Neighboring gene zinc finger protein 280D Neighboring gene diphosphoinositol pentakisphosphate kinase 1a Neighboring gene microtubule-associated protein 1Aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish. Sabharwal A, et al. Genes (Basel), 2022 Jul 23. PMID 35893052, Free PMC Article
    2. FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science. Ma AC, et al. Hum Gene Ther, 2016 Jun. PMID 26854857, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152651

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methionyl-tRNA formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionyl-tRNA formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methionyl-tRNA formyltransferase, mitochondrial
    NP_001071010.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077542.2 → NP_001071010.2  methionyl-tRNA formyltransferase, mitochondrial

      See identical proteins and their annotated locations for NP_001071010.2

      Status: VALIDATED

      Source sequence(s)
      BC142768, BC153525
      UniProtKB/TrEMBL
      A5PL71, A8E5A7
      Related
      ENSDARP00000053813.6, ENSDART00000053814.8
      Conserved Domains (3) summary
      cd08646
      Location:53 → 246
      FMT_core_Met-tRNA-FMT_N; Methionyl-tRNA formyltransferase, N-terminal hydrolase domain
      TIGR00460
      Location:54 → 358
      fmt; methionyl-tRNA formyltransferase
      pfam02911
      Location:247 → 348
      Formyl_trans_C; Formyl transferase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      52753073..52761572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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