msgn1 mesogenin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: msgn1provided by ZNC
Official Full Name: mesogenin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030722-1
See related: Ensembl:ENSDARG00000070546 AllianceGenome:ZFIN:ZDB-GENE-030722-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mespo; Meso1a; wu:fc39h09; zgc:109769
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within paraxial mesodermal cell differentiation; regulation of transcription by RNA polymerase II; and somatic muscle development. Predicted to be active in nucleus. Is expressed in several structures, including margin; mesoderm; myoblast; tail bud; and telencephalon. Orthologous to human MSGN1 (mesogenin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (306283..308006)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (292835..294558)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome.
Title: Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome.
Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.(
Title: Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.
Through its combined effects on gene expression and cell movement, Msgn1 (with Spt) plays a key role both in genesis of the paraxial mesoderm and in maintenance of the progenitor population from which it derives.
Title: The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1.
Msgn1 expression in association with that of ntl may allow the differentiation of progenitor cells to proceed during development of somites in the tail.
Title: Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites.
mespo expression is intensified in the involuting mesoderm at 60% epiboly, and then restricted to the presomitic mesoderm (PSM) at 95% epiboly. At the 1-somite stage, mespo expression becomes reduced in the most rostral PSM.
Title: Characterization and expression of a presomitic mesoderm-specific mespo gene in zebrafish.

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General gene information

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Markers

fc83b04.y1 (e-PCR)
- UniSTS:194596

fc39h09.x1 (e-PCR)
- UniSTS:193763

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesoderm formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within paraxial mesodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic muscle development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mesogenin-1

Names: mesP-related bHLH factor; pMeso1a; pMesogenin1; pMsgn1; paraxial mesoderm-specific expression and regulatory capacities

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.