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    c4b complement C4B (Chido/Rodgers blood group) [ Danio rerio (zebrafish) ]

    Gene ID: 794635, updated on 12-Sep-2024

    Summary

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    Official Symbol
    c4bprovided by ZNC
    Official Full Name
    complement C4B (Chido/Rodgers blood group)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100805-2
    See related
    Ensembl:ENSDARG00000038424 AllianceGenome:ZFIN:ZDB-GENE-100805-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    c4-2; c4bl; si:dkey-8k3.2
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement component 4b deficiency; and renal cell carcinoma. Orthologous to human C4B (complement C4B (Chido blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See c4b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (16665203..16701780, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (16757225..16793965, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 21, subfamily A, polypeptide 2 Neighboring gene tenascin XBa Neighboring gene urotensin-2 receptor 3 Neighboring gene potassium inwardly rectifying channel subfamily J member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fish complement C4 gene evolution and gene/protein regulatory network analyses and simulated stereo conformation of C4-MASP-2 protein complex. Li L, et al. Fish Shellfish Immunol, 2020 Dec. PMID 32980531
    2. Behavioral and physiological effects of acute and chronic kava exposure in adult zebrafish. Wang D, et al. Neurotoxicol Teratol, 2020 May-Jun. PMID 32240749
    3. Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling. Chernyavskaya Y, et al. Development, 2017 Aug 15. PMID 28698226, Free PMC Article
    4. Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Boswell M, et al. Sci Rep, 2020 Feb 24. PMID 32094353, Free PMC Article
    5. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Ho NY, et al. Environ Sci Technol, 2013 Apr 2. PMID 23458150

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement C4-B
    Names
    complement 4B (Chido blood group)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365137.1 → NP_001352066.1  complement C4-B

      Status: VALIDATED

      Source sequence(s)
      FP929006
      UniProtKB/TrEMBL
      A0A8M1Q1D0
      Related
      ENSDARP00000115743.1, ENSDART00000143550.3
      Conserved Domains (7) summary
      cd00017
      Location:667 → 735
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:982 → 1299
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      cd03584
      Location:1563 → 1715
      NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
      pfam00207
      Location:772 → 854
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:130 → 224
      A2M_N; MG2 domain
      pfam07677
      Location:1456 → 1545
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:452 → 593
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      16665203..16701780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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