agxta alanine--glyoxylate and serine--pyruvate aminotransferase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: agxtaprovided by ZNC
Official Full Name: alanine--glyoxylate and serine--pyruvate aminotransferase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-16
See related: Ensembl:ENSDARG00000052099 AllianceGenome:ZFIN:ZDB-GENE-040718-16
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: agxtl; zgc:91879
Summary: Predicted to enable L-serine-pyruvate transaminase activity and alanine-glyoxylate transaminase activity. Predicted to be involved in glycine biosynthetic process, by transamination of glyoxylate. Predicted to be active in peroxisome. Is expressed in liver and pronephric duct. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (27112884..27123307, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (27122323..27132746, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-serine-pyruvate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine-pyruvate transaminase activity	IEA Inferred from Electronic Annotation more info
enables alanine-glyoxylate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-glyoxylate transaminase activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycine biosynthetic process, by transamination of glyoxylate	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alanine--glyoxylate and serine--pyruvate aminotransferase a

Names: alanine-glyoxylate aminotransferase a; alanine-glyoxylate aminotransferase, like

NP_001002331.1

EC 2.6.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002331.1 → NP_001002331.1 alanine--glyoxylate and serine--pyruvate aminotransferase a

See identical proteins and their annotated locations for NP_001002331.1

Status: PROVISIONAL

Source sequence(s)

BC076465

UniProtKB/TrEMBL

Q6DG86

Related

ENSDARP00000068371.4, ENSDART00000073881.5

Conserved Domains (2) summary

cd06451
Location:22 → 384

AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...

COG0075
Location:16 → 386

PucG; Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG [Amino acid transport and metabolism, Nucleotide transport and metabolism]