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    aldh4a1 aldehyde dehydrogenase 4 family, member A1 [ Danio rerio (zebrafish) ]

    Gene ID: 394133, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aldh4a1provided by ZNC
    Official Full Name
    aldehyde dehydrogenase 4 family, member A1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1179
    See related
    Ensembl:ENSDARG00000038207 AllianceGenome:ZFIN:ZDB-GENE-040426-1179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63592
    Summary
    Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to act upstream of or within proline metabolic process. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aldh4a1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (41936435..41960282)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (41324318..41348165)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene intermediate filament family orphan 2b Neighboring gene hairy-related 2 Neighboring gene hairy and enhancer of split-related 15, tandem duplicate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption. Yan Y, et al. Oxid Med Cell Longev, 2022. PMID 35313640, Free PMC Article
    2. p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Ye S, et al. Cell Death Dis, 2020 Jul 23. PMID 32703938, Free PMC Article
    3. Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish. Zhao T, et al. Cell Death Dis, 2021 Feb 4. PMID 33542214, Free PMC Article
    4. Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin. Park J, et al. BMC Genomics, 2018 Oct 29. PMID 30373515, Free PMC Article
    5. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC63592

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proline metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Names
    L-glutamate gamma-semialdehyde dehydrogenase
    P5C dehydrogenase
    aldehyde dehydrogenase 4A1
    aldehyde dehydrogenase family 4 member A1
    NP_957452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201158.1 → NP_957452.1  delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_957452.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055155
      UniProtKB/Swiss-Prot
      Q7SY23
      Related
      ENSDARP00000142254.2, ENSDART00000173103.2
      Conserved Domains (1) summary
      cd07123
      Location:25 → 546
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      41936435..41960282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SY23.1 GenPept UniProtKB/Swiss-Prot:Q7SY23

    Gene LinkOut

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