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    kyat3.2 kynurenine aminotransferase 3, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 393315, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kyat3.2provided by ZNC
    Official Full Name
    kynurenine aminotransferase 3, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1299
    See related
    Ensembl:ENSDARG00000101791 AllianceGenome:ZFIN:ZDB-GENE-040426-1299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ccbl2; kyat3; zgc:63929
    Summary
    Predicted to enable kynurenine-glyoxylate transaminase activity and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in kynurenine metabolic process. Predicted to act upstream of or within biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including lens; liver; midbrain neural keel; myotome; and solid lens vesicle. Orthologous to human KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See kyat3.2 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (25257709..26069938)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (25271780..25276860)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene kynurenine--oxoglutarate transaminase 3 Neighboring gene leucine rich repeat containing 8 VRAC subunit C Neighboring gene kynurenine aminotransferase 3, tandem duplicate 1 Neighboring gene protein kinase N2b Neighboring gene uncharacterized LOC137495969 Neighboring gene LIM domain only 4b Neighboring gene heparan sulfate 2-O-sulfotransferase 1b Neighboring gene uncharacterized LOC137495970 Neighboring gene DAZ interacting zinc finger protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. He T, et al. Int J Mol Sci, 2023 Jan 20. PMID 36768377, Free PMC Article
    2. Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation. Huang CX, et al. Life Sci, 2017 Feb 15. PMID 28077310
    3. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Zhang D, et al. Mech Dev, 2017 Feb. PMID 28132765
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63929

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-glyoxylate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-glyoxylate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase 3
    Names
    KATIII
    cysteine conjugate-beta lyase 2
    cysteine-S-conjugate beta-lyase 2
    kynurenine aminotransferase 3
    kynurenine aminotransferase III
    kynurenine--glyoxylate transaminase
    kynurenine--oxoglutarate transaminase III
    NP_956638.2
    XP_005168814.1
    XP_005168815.1
    XP_021332476.1
    XP_068077769.1
    XP_068077771.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200344.2 → NP_956638.2  kynurenine--oxoglutarate transaminase 3

      Status: VALIDATED

      Source sequence(s)
      CR450763
      UniProtKB/Swiss-Prot
      Q7T3E5
      UniProtKB/TrEMBL
      A0A8M1PEC5
      Related
      ENSDARP00000135662.1, ENSDART00000157790.2
      Conserved Domains (2) summary
      cd00609
      Location:64 → 445
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:58 → 450
      PRK08912; hypothetical protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      25257709..26069938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168757.5 → XP_005168814.1  kynurenine--oxoglutarate transaminase 3 isoform X2

      UniProtKB/Swiss-Prot
      Q7T3E5
      UniProtKB/TrEMBL
      A0A8M2BG14
      Conserved Domains (2) summary
      cd00609
      Location:36 → 417
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:30 → 422
      PRK08912; hypothetical protein; Provisional

    2. XM_021476801.2 → XP_021332476.1  kynurenine--oxoglutarate transaminase 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M9QA74
      Conserved Domains (1) summary
      cl27741
      Location:1 → 352
      Aminotran_1_2; Aminotransferase class I and II

    3. XM_068221668.1 → XP_068077769.1  kynurenine--oxoglutarate transaminase 3 isoform X1

    4. XM_005168758.5 → XP_005168815.1  kynurenine--oxoglutarate transaminase 3 isoform X3

      UniProtKB/Swiss-Prot
      Q7T3E5
      UniProtKB/TrEMBL
      A0A8M2BG21
      Conserved Domains (2) summary
      cd00609
      Location:33 → 414
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:27 → 419
      PRK08912; hypothetical protein; Provisional

    5. XM_068221670.1 → XP_068077771.1  kynurenine--oxoglutarate transaminase 3 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T3E5.2 GenPept UniProtKB/Swiss-Prot:Q7T3E5

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