pomca proopiomelanocortin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pomcaprovided by ZNC
Official Full Name: proopiomelanocortin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030513-2
See related: Ensembl:ENSDARG00000043135 AllianceGenome:ZFIN:ZDB-GENE-030513-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: MSH; ACTH; pomc; SI:bZ36D5.1; SI:bZ36D5.4; si:bz36d5.2
Summary: Enables neuropeptide hormone activity. Acts upstream of or within several processes, including melanosome localization; neuropeptide signaling pathway; and regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Is expressed in several structures, including adenohypophyseal placode; adrenal medulla cell; bone tissue; endocrine system; and hypothalamus. Used to study hyperandrogenism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (33226955..33230034)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (33272084..33277595)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity.
Title: Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity.
The evolution of pomc, pmch and pmchl genes and acquisition of hormonal status for MCHL explain different mechanisms used by vertebrates to background-adapt
Title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Title: Enhancer turnover and conserved regulatory function in vertebrate evolution.
Hypothalamic pro-opiomelanocortin and AgRP neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
Title: AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Title: In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal.
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Title: Identification of two proopiomelanocortin genes in zebrafish (Danio rerio).
cloning and characterization of the pro-opiomelanocortin gene
Title: The pro-opiomelanocortin gene of the zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within melanosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proopiomelanocortin a

Names: beta-endorphin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181438.3 → NP_852103.1 proopiomelanocortin a precursor

See identical proteins and their annotated locations for NP_852103.1

Status: PROVISIONAL

Source sequence(s)

BC133874

UniProtKB/TrEMBL

A3KNJ4, Q7ZT18

Related

ENSDARP00000063332.5, ENSDART00000063333.7

Conserved Domains (3) summary

pfam00976
Location:171 → 189

ACTH_domain; Corticotropin ACTH domain

pfam08035
Location:190 → 219

Op_neuropeptide; Opioids neuropeptide

pfam08384
Location:30 → 72

NPP; Pro-opiomelanocortin, N-terminal region