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    col14a1a collagen, type XIV, alpha 1a [ Danio rerio (zebrafish) ]

    Gene ID: 321298, updated on 2-Nov-2024

    Summary

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    Official Symbol
    col14a1aprovided by ZNC
    Official Full Name
    collagen, type XIV, alpha 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9889
    See related
    Ensembl:ENSDARG00000005762 AllianceGenome:ZFIN:ZDB-GENE-030131-9889
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb382; cb542; col14a1; sb:cb382; sb:cb542
    Summary
    Acts upstream of or within basement membrane assembly. Located in basement membrane. Is expressed in several structures, including integument; median fin fold; nervous system; pectoral fin bud; and pharyngeal arch. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human COL14A1 (collagen type XIV alpha 1 chain). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See col14a1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (14707867..15050844)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (14817702..15158601)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene uncharacterized LOC137487886 Neighboring gene uncharacterized LOC137487260 Neighboring gene uncharacterized LOC110437976 Neighboring gene uncharacterized LOC101886692 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene MDM2 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes. Bader HL, et al. Matrix Biol, 2009 Jan. PMID 18983916
    2. Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. Mei X, et al. Dis Model Mech, 2013 May. PMID 23324328, Free PMC Article
    3. Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane. Nauroy P, et al. Matrix Biol, 2019 Jan. PMID 30031067
    4. Zebrafish collagen XIV is transiently expressed in epithelia and is required for proper function of certain basement membranes. Bader HL, et al. J Biol Chem, 2013 Mar 8. PMID 23325806, Free PMC Article
    5. Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction. Charvet B, et al. Development, 2013 Nov. PMID 24131632

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of our CRISPR/Cas9-mediated col14a1a knockout fish showed that collagen XIV-A contributes to timely deposition of laminins. As changes in ECM organization can affect tissue mechanical properties, we analyzed the biomechanics of col14a1a(-/-) regenerative BM using atomic force microscopy (AFM).
      Title: Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane.
    2. Data indicate that duplicate col14a1 genes col14a1a (id 321298; XM_001922011 on chromosome 16) and col14a1b (id 100331704; XM_003200499 on chromosome 19) are differentially expressed during embryogenesis.
      Title: Zebrafish collagen XIV is transiently expressed in epithelia and is required for proper function of certain basement membranes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within basement membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in interstitial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    collagen alpha-1(XIV) chain
    Names
    collagen, type XIV, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      14707867..15050844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292164.4 → XP_009290439.1  collagen alpha-1(XIV) chain isoform X6

      UniProtKB/TrEMBL
      A0A8M3AHX6
      Conserved Domains (5) summary
      pfam01391
      Location:1530 → 1619
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:1229 → 1424
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:157 → 320
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:626 → 700
      fn3; Fibronectin type III domain

    2. XM_009292161.4 → XP_009290436.1  collagen alpha-1(XIV) chain isoform X1

      UniProtKB/TrEMBL
      A0A8M3AIZ5
      Conserved Domains (5) summary
      pfam01391
      Location:1530 → 1619
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:1229 → 1424
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:157 → 320
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:626 → 700
      fn3; Fibronectin type III domain

    3. XM_009292162.4 → XP_009290437.1  collagen alpha-1(XIV) chain isoform X3

      UniProtKB/TrEMBL
      A0A8M3AT92, F1R9Y1
      Related
      ENSDARP00000017432.6, ENSDART00000027982.9
      Conserved Domains (5) summary
      pfam01391
      Location:1515 → 1604
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:1229 → 1424
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:157 → 320
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:626 → 700
      fn3; Fibronectin type III domain

    4. XM_068214100.1 → XP_068070201.1  collagen alpha-1(XIV) chain isoform X2

    5. XM_009292163.4 → XP_009290438.1  collagen alpha-1(XIV) chain isoform X4

      UniProtKB/TrEMBL
      A0A8M3AQF5
      Conserved Domains (5) summary
      pfam01391
      Location:1530 → 1619
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:1229 → 1424
      TSPN; Thrombospondin N-terminal -like domains
      cd00063
      Location:538 → 617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01482
      Location:157 → 320
      vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
      pfam00041
      Location:626 → 700
      fn3; Fibronectin type III domain

    6. XM_068214101.1 → XP_068070202.1  collagen alpha-1(XIV) chain isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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