ralgapa1 Ral GTPase activating protein catalytic subunit alpha 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ralgapa1provided by ZNC
Official Full Name: Ral GTPase activating protein catalytic subunit alpha 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-080806-1
See related: Ensembl:ENSDARG00000076889 AllianceGenome:ZFIN:ZDB-GENE-080806-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GARNL1; tulip1; tulip1.2
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within brain development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in head. Orthologous to human RALGAPA1 (Ral GTPase activating protein catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (12767485..12923574)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (12613574..12769508)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A full-length homolog of human TULIP1 was identified in zebrafish with 72% identity to human. Tulip1 was highly expressed in zebrafish brain, and knockdown of which resulted in brain developmental delay.
Title: TULIP1 (RALGAPA1) haploinsufficiency with brain development delay.

Submit: New GeneRIF Correction

General gene information

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Markers

fc59g10 (e-PCR)
- UniSTS:189451

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ral GTPase-activating protein subunit alpha-1

Names: GTPase activating Rap/RanGAP domain-like 1; Ral GTPase activating protein, alpha subunit 1 (catalytic); tuberin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

12767485..12923574

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467314.2 → XP_021322989.1 ral GTPase-activating protein subunit alpha-1 isoform X1

UniProtKB/TrEMBL

A0A8M9PEK4

Related

ENSDARP00000150677.1, ENSDART00000179686.1

Conserved Domains (1) summary

pfam02145
Location:1896 → 2069

Rap_GAP; Rap/ran-GAP
XM_021467317.2 → XP_021322992.1 ral GTPase-activating protein subunit alpha-1 isoform X3

UniProtKB/TrEMBL

A0A8M9P0D7

Related

ENSDARP00000128916.1, ENSDART00000154984.3

Conserved Domains (1) summary

pfam02145
Location:1849 → 2022

Rap_GAP; Rap/ran-GAP
XM_021467316.2 → XP_021322991.1 ral GTPase-activating protein subunit alpha-1 isoform X2

UniProtKB/TrEMBL

A0A8M9PL46

Related

ENSDARP00000101097.2, ENSDART00000112469.4

Conserved Domains (1) summary

pfam02145
Location:1849 → 2022

Rap_GAP; Rap/ran-GAP

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001146304.1: Suppressed sequence

Description

NM_001146304.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: RALGAPA1 (GeneID:253959).