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    eps8l3b EPS8 signaling adaptor L3b [ Danio rerio (zebrafish) ]

    Gene ID: 393332, updated on 2-Nov-2024

    Summary

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    Official Symbol
    eps8l3bprovided by ZNC
    Official Full Name
    EPS8 signaling adaptor L3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1335
    See related
    Ensembl:ENSDARG00000005704 AllianceGenome:ZFIN:ZDB-GENE-040426-1335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    eps8l3; zgc:64011
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to be active in ruffle membrane. Is expressed in gut; intestinal bulb; liver; pronephric duct; and pronephros. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 signaling adaptor L3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See eps8l3b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (25310811..25329975, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (25291672..25311173, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase mu tandem duplicate 2 Neighboring gene glutathione S-transferase mu tandem duplicate 3 Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene TRAF3 interacting protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The construction of intrahepatic cholangiocarcinoma model in zebrafish. Wang J, et al. Sci Rep, 2017 Oct 17. PMID 29042681, Free PMC Article
    2. Transcriptional profiling of the zebrafish proximal tubule. Sander V, et al. Am J Physiol Renal Physiol, 2019 Aug 1. PMID 31188030
    3. Eumetazoan cryptochrome phylogeny and evolution. Haug MF, et al. Genome Biol Evol, 2015 Jan 18. PMID 25601102, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC64011

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8-like protein 3b
    Names
    EPS8-like 3
    EPS8-like 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328079.1 → NP_001315008.1  epidermal growth factor receptor kinase substrate 8-like protein 3b

      Status: VALIDATED

      Source sequence(s)
      CR847543
      UniProtKB/TrEMBL
      A0A8M1P9W0, B8JIS3
      Related
      ENSDARP00000114441.1, ENSDART00000139682.2
      Conserved Domains (3) summary
      cd11764
      Location:481 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:47 → 176
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:550 → 612
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      25310811..25329975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167020.5 → XP_005167077.1  epidermal growth factor receptor kinase substrate 8-like protein 3b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BF07
      Conserved Domains (3) summary
      cd11764
      Location:481 → 534
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:47 → 176
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:549 → 611
      SAM_superfamily; SAM (Sterile alpha motif )

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_200361.1: Suppressed sequence

      Description
      NM_200361.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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