klhl41b kelch-like family member 41b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klhl41bprovided by ZNC
Official Full Name: kelch-like family member 41bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9875
See related: Ensembl:ENSDARG00000006757 AllianceGenome:ZFIN:ZDB-GENE-030131-9875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb52; kbtbd10; sb:cb52; kbtbd10b; sarcosin; wu:fb24f05; wu:fc15e07
Summary: Acts upstream of or within sarcomere organization and skeletal muscle fiber development. Predicted to be located in cytoskeleton and sarcoplasmic reticulum membrane. Is expressed in adaxial cell; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (3680554..3690209)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (3519734..3529389)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI657596 (e-PCR)
- UniSTS:206107

fb24f05.x1 (e-PCR)
- UniSTS:203088

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kelch-like protein 41b

Names: kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB (POZ) domain containing 10b; kelch repeat and BTB domain-containing protein 10b; kelch-like 41b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198979.1 → NP_945330.1 kelch-like protein 41b

See identical proteins and their annotated locations for NP_945330.1

Status: PROVISIONAL

Source sequence(s)

BC054912

UniProtKB/Swiss-Prot

F1QEG2, Q7SYD2

Related

ENSDARP00000012238.5, ENSDART00000013588.7

Conserved Domains (6) summary

PHA03098
Location:46 → 528

PHA03098; kelch-like protein; Provisional

sd00038
Location:387 → 432

Kelch; KELCH repeat [structural motif]

pfam00651
Location:22 → 128

BTB; BTB/POZ domain

pfam01344
Location:483 → 521

Kelch_1; Kelch motif

pfam07707
Location:136 → 238

BACK; BTB And C-terminal Kelch

pfam13964
Location:437 → 484

Kelch_6; Kelch motif