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    adka adenosine kinase a [ Danio rerio (zebrafish) ]

    Gene ID: 368220, updated on 2-Nov-2024

    Summary

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    Official Symbol
    adkaprovided by ZNC
    Official Full Name
    adenosine kinase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030425-3
    See related
    Ensembl:ENSDARG00000039429 AllianceGenome:ZFIN:ZDB-GENE-030425-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    adk; cb163; wu:fb39g06; wu:fb57c05; wu:fc10c08; wu:fc41g07; wu:fi37c12
    Summary
    Predicted to enable adenosine kinase activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to act upstream of or within phosphorylation and purine ribonucleoside salvage. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including digestive system; fin; immature eye; nervous system; and periderm. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See adka in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (24918594..25199279, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (24788144..25068829, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene dual specificity protein phosphatase 13B-like Neighboring gene dual specificity phosphatase 13a Neighboring gene K(lysine) acetyltransferase 6B Neighboring gene adaptor related protein complex 3 subunit mu 1 Neighboring gene vinculin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Schmitt CE, et al. Mol Cells, 2013 Feb. PMID 23456338, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC191204

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine kinase
    NP_001259013.1
    NP_997956.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272084.1 → NP_001259013.1  adenosine kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL929334, CR788251
      UniProtKB/TrEMBL
      A0A0R4IYX1, A0A8M1NZA9
      Related
      ENSDARP00000140675.1, ENSDART00000159585.2
      Conserved Domains (2) summary
      PTZ00247
      Location:9 → 344
      PTZ00247; adenosine kinase; Provisional
      cl00192
      Location:12 → 344
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    2. NM_212791.2 → NP_997956.1  adenosine kinase isoform 1

      See identical proteins and their annotated locations for NP_997956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AL929334, CR788251
      UniProtKB/TrEMBL
      A0A8M1PHW6, Q6P3J9
      Related
      ENSDARP00000057604.5, ENSDART00000057605.7
      Conserved Domains (2) summary
      PTZ00247
      Location:23 → 358
      PTZ00247; adenosine kinase; Provisional
      cl00192
      Location:26 → 358
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      24918594..25199279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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