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    ing4 inhibitor of growth family, member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 322113, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ing4provided by ZNC
    Official Full Name
    inhibitor of growth family, member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-47
    See related
    Ensembl:ENSDARG00000030716 AllianceGenome:ZFIN:ZDB-GENE-050522-47
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb11d09; wu:fb50e02; zgc:110619
    Summary
    Predicted to enable methylated histone binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in nucleus. Orthologous to human ING4 (inhibitor of growth family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ing4 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (9512982..9522548, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (9594062..9603619, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene vesicle associated membrane protein 1a Neighboring gene intermediate filament family orphan 1a Neighboring gene family with sequence similarity 131 member Ba Neighboring gene chloride channel, voltage-sensitive 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular Physiology of an Extra-renal Cl(-) Uptake Mechanism for Body Fluid Cl(-) Homeostasis. Wang YF, et al. Int J Biol Sci, 2015. PMID 26327813, Free PMC Article
    2. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020468.2 → NP_001018304.1  inhibitor of growth protein 4

      See identical proteins and their annotated locations for NP_001018304.1

      Status: VALIDATED

      Source sequence(s)
      CR388038, EH590713, EH608189
      UniProtKB/TrEMBL
      B2GSB1, Q4VBS0
      Related
      ENSDARP00000045244.4, ENSDART00000045245.5
      Conserved Domains (3) summary
      COG5034
      Location:7 → 246
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15684
      Location:198 → 245
      PHD_ING4; PHD finger found in inhibitor of growth protein 4 (ING4)
      pfam12998
      Location:6 → 105
      ING; Inhibitor of growth proteins N-terminal histone-binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      9512982..9522548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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