grhl1 grainyhead-like transcription factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grhl1provided by ZNC
Official Full Name: grainyhead-like transcription factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3665
See related: Ensembl:ENSDARG00000061391 AllianceGenome:ZFIN:ZDB-GENE-030131-3665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc49a04; wu:fc49a04
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including desmosome organization; epiboly; and inner ear development. Located in cytoplasm. Is expressed in several structures, including epidermal cell; head; integument; pronephric duct; and sensory system. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (32391052..32426415, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (32438514..32473916, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that grhl1 is a novel common marker of all or most "non-keratinocyte" epidermal progenitors, and that the sub-functionalisation of these cells is regulated by differential positive and negative effects of Foxi3 factors.
Title: Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within desmosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epidermis development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within keratinocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: grainyhead-like protein 1 homolog

Names: grainyhead-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305567.1 → NP_001292496.1 grainyhead-like protein 1 homolog

Status: VALIDATED

Source sequence(s)

AW595322, CR627496

UniProtKB/TrEMBL

A0A286YAF2, A0A8M1P6C3

Related

ENSDARP00000144151.2, ENSDART00000179314.2

Conserved Domains (1) summary

pfam04516
Location:241 → 430

CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

32391052..32426415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001923728.6 → XP_001923763.1 grainyhead-like protein 1 homolog isoform X1

UniProtKB/TrEMBL

A0A8M1QLT7, E7FCE3

Related

ENSDARP00000124180.1, ENSDART00000148455.3

Conserved Domains (1) summary

pfam04516
Location:241 → 432

CP2; CP2 transcription factor