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    chrna7a cholinergic receptor, nicotinic, alpha 7a (neuronal) [ Danio rerio (zebrafish) ]

    Gene ID: 394199, updated on 2-Nov-2024

    Summary

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    Official Symbol
    chrna7aprovided by ZNC
    Official Full Name
    cholinergic receptor, nicotinic, alpha 7a (neuronal)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040108-3
    See related
    Ensembl:ENSDARG00000101702 AllianceGenome:ZFIN:ZDB-GENE-040108-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    chrna7; dZ70B1.1
    Summary
    Contributes to acetylcholine receptor activity. Acts upstream of or within response to nicotine. Part of acetylcholine-gated channel complex. Is expressed in brain; neuromast; spinal cord; and spinal cord neural tube. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See chrna7a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (53641257..53669653, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (53371605..53400001, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 609b Neighboring gene GRAM domain containing 2Aa Neighboring gene uncharacterized LOC110439947 Neighboring gene neogenin 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Acetylcholine potentiates glutamate transmission from the habenula to the interpeduncular nucleus in losers of social conflict. Kinoshita M, et al. Curr Biol, 2023 Jun 5. PMID 37105168
    2. The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors. Ponzoni L, et al. Psychopharmacology (Berl), 2014 Dec. PMID 24862365
    3. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Viscarra F, et al. Molecules, 2020 Jun 30. PMID 32630020, Free PMC Article
    4. Cloning and expression of zebrafish neuronal nicotinic acetylcholine receptors. Zirger JM, et al. Gene Expr Patterns, 2003 Dec. PMID 14643683
    5. Tethering naturally occurring peptide toxins for cell-autonomous modulation of ion channels and receptors in vivo. Ibañez-Tallon I, et al. Neuron, 2004 Aug 5. PMID 15294139

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sinomenine Hydrochloride Ameliorates Fish Foodborne Enteritis via alpha7nAchR-Mediated Anti-Inflammatory Effect Whilst Altering Microbiota Composition.
      Title: Sinomenine Hydrochloride Ameliorates Fish Foodborne Enteritis via α7nAchR-Mediated Anti-Inflammatory Effect Whilst Altering Microbiota Composition.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to nicotine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal acetylcholine receptor subunit alpha-7a
    Names
    cholinergic receptor, nicotinic, alpha 7 (neuronal)
    cholinergic receptor, nicotinic, alpha polypeptide 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201219.2 → NP_957513.1  neuronal acetylcholine receptor subunit alpha-7a

      See identical proteins and their annotated locations for NP_957513.1

      Status: PROVISIONAL

      Source sequence(s)
      AY247962
      UniProtKB/TrEMBL
      Q800C7
      Related
      ENSDARP00000139906.1, ENSDART00000171463.3
      Conserved Domains (3) summary
      TIGR00860
      Location:3 → 496
      LIC; Cation transporter family protein
      pfam02931
      Location:26 → 230
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:237 → 492
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      53641257..53669653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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