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    SQS1 Sqs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855497, updated on 17-May-2024

    Summary

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    Gene symbol
    SQS1
    Gene description
    Sqs1p
    Primary source
    FungiDB:YNL224C
    Locus tag
    YNL224C
    See related
    SGD:S000005168; AllianceGenome:SGD:S000005168; VEuPathDB:YNL224C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PFA1
    Summary
    Predicted to enable nucleic acid binding activity. Involved in RNA processing; positive regulation of ATPase activity; and positive regulation of helicase activity. Located in cytoplasm and nucleolus. Part of 90S preribosome; preribosome, large subunit precursor; and preribosome, small subunit precursor. Orthologous to human GPATCH2 (G-patch domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SQS1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (224796..227099, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Jjj1p Neighboring gene Cnm67p Neighboring gene cysteine protease ATG4 Neighboring gene RNA polymerase II subunit A C-terminal domain phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prp43p contains a processive helicase structural architecture with a specific regulatory domain. Walbott H, et al. EMBO J, 2010 Jul 7. PMID 20512115, Free PMC Article
    2. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase. Mouffok S, et al. RNA Biol, 2021 Apr. PMID 32882145, Free PMC Article
    3. Limited portability of G-patch domains in regulators of the Prp43 RNA helicase required for pre-mRNA splicing and ribosomal RNA maturation in Saccharomyces cerevisiae. Banerjee D, et al. Genetics, 2015 May. PMID 25808954, Free PMC Article
    4. RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1. Pertschy B, et al. J Biol Chem, 2009 Dec 11. PMID 19801658, Free PMC Article
    5. The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis. Lebaron S, et al. EMBO J, 2009 Dec 16. PMID 19927118, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
      Title: The G-patch activators Pfa1 and PINX1 exhibit different modes of interaction with the Prp43 RNA helicase.
    2. Data report that cleavage of pre-rRNA at the 3'-end of 18 S rRNA, requires functional interactions between Nob1 and Prp43, and the cofactor Pfa1.
      Title: RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.
    3. stimulation of ATPase/helicase activities of Prp43p by Pfa1p is required for efficient 20S pre-rRNA-to-18S rRNA conversion
      Title: The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of preribosome, small subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sqs1p
    NP_014175.1
    • Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      224796..227099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183062.1 → NP_014175.1  TPA: Sqs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZRL6, D6W0W6, P53866
      UniProtKB/TrEMBL
      A0A8H4BVJ0, B3LP68, N1NY27
      Conserved Domains (2) summary
      cd02646
      Location:597 → 654
      R3H_G-patch; R3H domain of a group of fungal and plant proteins with unknown function, who also contain a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the R3H ...
      pfam01585
      Location:721 → 764
      G-patch; G-patch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53866.1

    Gene LinkOut

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