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    cdc22 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541695, updated on 11-Sep-2024

    Summary

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    Official Symbol
    cdc22
    Primary source
    PomBase:SPAC1F7.05
    Locus tag
    SPOM_SPAC1F7.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (4226970..4229989)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho family GTPase Rho1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ThiJ domain protein, glyoxylase III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cdc 22 mutation by Schizosaccharomyces pombe is a temperature-sensitive defect in nucleoside diphosphokinase. Dickinson JR. Eur J Biochem, 1981 Oct. PMID 6273154
    2. Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated. Fleck O, et al. J Cell Sci, 2013 Nov 1. PMID 23986475, Free PMC Article
    3. Characterisation of the Schizosaccharomyces pombe rad4/cut5 mutant phenotypes: dissection of DNA replication and G2 checkpoint control function. McFarlane RJ, et al. Mol Gen Genet, 1997 Jul. PMID 9268024
    4. The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit. Håkansson P, et al. J Biol Chem, 2006 Jan 20. PMID 16317005
    5. Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited. Moynihan EB, et al. Mol Biol Cell, 1999 Feb. PMID 9950674, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spd1 accumulation causes genome instability independently of cdc22 activity.
      Title: Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.
    2. Spd1p inhibits fission yeast ribonucleotide reductase activity by interacting with the Cdc22p.
      Title: The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to CDP reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dCDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTTP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    part_of ribonucleoside-diphosphate reductase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoside-diphosphate reductase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonucleoside reductase large subunit Cdc22

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4226970..4229989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019920.3 → NP_594491.1  ribonucleoside reductase large subunit Cdc22 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594491.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36602
      UniProtKB/TrEMBL
      S6BSK3
      Conserved Domains (3) summary
      cd01679
      Location:167 → 740
      RNR_I; Class I ribonucleotide reductase
      PLN02437
      Location:1 → 811
      PLN02437; ribonucleoside--diphosphate reductase large subunit
      pfam03477
      Location:1 → 89
      ATP-cone; ATP cone domain
    Nucleotide Protein
    Heading Accession and Version

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