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    TRS130 transport protein particle complex II subunit TRS130 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855258, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TRS130
    Official Full Name
    transport protein particle complex II subunit TRS130
    Primary source
    SGD:S000004831
    Locus tag
    YMR218C
    See related
    AllianceGenome:SGD:S000004831; FungiDB:YMR218C; VEuPathDB:YMR218C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to guanyl-nucleotide exchange factor activity. Involved in Golgi vesicle transport; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in early endosome and trans-Golgi network. Part of TRAPPII protein complex. Orthologous to human TRAPPC10 (trafficking protein particle complex subunit 10). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See TRS130 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (703579..706887, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase SKY1 Neighboring gene GMP synthase (glutamine-hydrolyzing) Neighboring gene Esc1p Neighboring gene phosphomevalonate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutants in trs120 disrupt traffic from the early endosome to the late Golgi. Cai H, et al. J Cell Biol, 2005 Dec 5. PMID 16314430, Free PMC Article
    2. Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts. Milev MP, et al. J Med Genet, 2018 Nov. PMID 30120216
    3. Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex. Cox R, et al. BMC Evol Biol, 2007 Feb 2. PMID 17274825, Free PMC Article
    4. Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae. Yamamoto K, et al. Curr Genet, 2002 Nov. PMID 12478387
    5. Modular TRAPP complexes regulate intracellular protein trafficking through multiple Ypt/Rab GTPases in Saccharomyces cerevisiae. Zou S, et al. Genetics, 2012 Jun. PMID 22426882, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trs130 mutants do not transport Atg8 and Atg9 to the pre-autophagosomal structure/phagophore assembly site.
      Title: Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPPII protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPII protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transport protein particle complex II subunit TRS130
    NP_013945.1
    • Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      703579..706887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182725.1 → NP_013945.1  TPA: transport protein particle complex II subunit TRS130 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W043, Q03660
      UniProtKB/TrEMBL
      B5VPY5
      Conserved Domains (1) summary
      pfam12584
      Location:1003 → 1101
      TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03660.1

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