U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    YVC1 Yvc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854255, updated on 1-Aug-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    YVC1
    Gene description
    Yvc1p
    Primary source
    FungiDB:YOR087W
    Locus tag
    YOR087W
    See related
    SGD:S000005613; AllianceGenome:SGD:S000005613; VEuPathDB:YOR087W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR088W
    Summary
    Enables channel activity. Involved in calcium ion transmembrane import into cytosol. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); migraine (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Orthologous to several human genes including TRPC5 (transient receptor potential cation channel subfamily C member 5); TRPV1 (transient receptor potential cation channel subfamily V member 1); and TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See YVC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (487707..489734)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tricalbin Neighboring gene tRNA-Asn Neighboring gene Rab family GTPase VPS21 Neighboring gene type 2C protein phosphatase PTC5

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Ahmed T, et al. Structure, 2022 Jan 6. PMID 34453887, Free PMC Article
    2. Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel. Amini M, et al. iScience, 2019 Jan 25. PMID 30572205, Free PMC Article
    3. The core domain as the force sensor of the yeast mechanosensitive TRP channel. Su Z, et al. J Gen Physiol, 2011 Dec. PMID 22124118, Free PMC Article
    4. Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1. Chang Y, et al. FEBS Lett, 2010 May 17. PMID 20035756
    5. Mechanical force and cytoplasmic Ca(2+) activate yeast TRPY1 in parallel. Su Z, et al. J Membr Biol, 2009 Feb. PMID 19219385

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
      Title: Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
    2. Data show that Ca(2+) on the lumen side inhibited channel activity of vacuolar cation channel TRPY1 protein (Yvc1 protein).
      Title: In vitro and in vivo characterization of modulation of the vacuolar cation channel TRPY1 from Saccharomyces cerevisiae.
    3. Yvc1p has nine cysteine residues, of which eight are located in the cytoplasmic regions and one on the transmembrane domain. We show that three of these cysteines, Cys-17, Cys-79, and Cys-191, are specifically glutathionylated.
      Title: Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane import into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Yvc1p
    NP_014730.2
    • Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      487707..489734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183506.1 → NP_014730.2  TPA: Yvc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014730.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2E9, Q08500, Q12324, Q7LGN3
      UniProtKB/TrEMBL
      A6ZNT8, B3LJD4, B5VRY3, C7GMP6, N1NVS1
      Conserved Domains (1) summary
      pfam00520
      Location:235 → 470
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12324.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous