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    mlh1 MutL family protein Mlh1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539949, updated on 22-Jun-2024

    Summary

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    Gene symbol
    mlh1
    Gene description
    MutL family protein Mlh1
    Locus tag
    SPOM_SPBC1703.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPBC1703.04
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    Genomic context

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    See mlh1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (2921230..2923544)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene RSC complex subunit Rsc9 Neighboring gene ncRNA Neighboring gene ARM-like repeat-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RIO family protein kinase Neighboring gene F-box/WD repeat protein Pof10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different frameshift mutation spectra in non-repetitive DNA of MutSalpha- and MutLalpha-deficient fission yeast cells. Marti TM, et al. DNA Repair (Amst), 2003 May 13. PMID 12713814
    2. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
    3. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
    4. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiosis I cell cycle process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    MutL family protein Mlh1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2921230..2923544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022118.3 → NP_596199.1  MutL family protein Mlh1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596199.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P78862, Q9P7W6
      Conserved Domains (4) summary
      COG0323
      Location:7 → 684
      MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
      cd03483
      Location:220 → 346
      MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
      pfam16413
      Location:445 → 684
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
      cl00075
      Location:29 → 156
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    Nucleotide Protein
    Heading Accession and Version

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