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    STK38L serine/threonine kinase 38 like [ Homo sapiens (human) ]

    Gene ID: 23012, updated on 28-Oct-2024

    Summary

    Official Symbol
    STK38Lprovided by HGNC
    Official Full Name
    serine/threonine kinase 38 likeprovided by HGNC
    Primary source
    HGNC:HGNC:17848
    See related
    Ensembl:ENSG00000211455 MIM:615836; AllianceGenome:HGNC:17848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDR2
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and negative regulation of autophagy. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See STK38L in Genome Data Viewer
    Location:
    12p11.23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (27244286..27325959)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (27116250..27197594)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27397219..27478892)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nontranscribed chromatin-defined enhancer upstream of C12orf71 Neighboring gene liprin-beta-1-like Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_27027 Neighboring gene chromosome 12 open reading frame 71 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:27366569-27367070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6143 Neighboring gene Sharpr-MPRA regulatory region 14756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6144 Neighboring gene MPRA-validated peak1626 silencer Neighboring gene uncharacterized LOC124902905 Neighboring gene uncharacterized LOC124902906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4310 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4311 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_27082 Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene BMAL2 antisense RNA 1 Neighboring gene single-pass membrane protein with coiled-coil domains 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cellular component organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 38-like
    Names
    NDR2 protein kinase
    nuclear Dbf2-related 2
    nuclear Dbf2-related kinase 2
    NP_055815.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015000.4NP_055815.1  serine/threonine-protein kinase 38-like

      See identical proteins and their annotated locations for NP_055815.1

      Status: VALIDATED

      Source sequence(s)
      AB023182, BU681056, BX390969
      Consensus CDS
      CCDS31761.1
      UniProtKB/Swiss-Prot
      A8K4U0, B4E3J8, Q8TBX7, Q9Y2H1
      Related
      ENSP00000373684.3, ENST00000389032.8
      Conserved Domains (1) summary
      cd05627
      Location:87452
      STKc_NDR2; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      27244286..27325959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      27116250..27197594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)