U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rbl1 retinoblastoma-like 1 (p107) [ Danio rerio (zebrafish) ]

    Gene ID: 795522, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rbl1provided by ZNC
    Official Full Name
    retinoblastoma-like 1 (p107)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8179
    See related
    Ensembl:ENSDARG00000008141 AllianceGenome:ZFIN:ZDB-GENE-030131-8179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj58e06; wu:fj58e06
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and negative regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle; regulation of cell division; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Orthologous to human RBL1 (RB transcriptional corepressor like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rbl1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (51548575..51573984, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (51549204..51573976, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495894 Neighboring gene si:dkey-6e2.2 Neighboring gene chromodomain helicase DNA binding protein 6 Neighboring gene RIPOR family member 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Duffy KT, et al. Nucleic Acids Res, 2005. PMID 16284195, Free PMC Article
    2. Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish. Hu SN, et al. FEBS Lett, 2012 Feb 3. PMID 22209980
    3. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
    4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    retinoblastoma-like protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130610.1 → NP_001124082.1  retinoblastoma-like protein 1

      Status: PROVISIONAL

      Source sequence(s)
      BC162986
      UniProtKB/TrEMBL
      B3DI38
      Related
      ENSDARP00000068355.3, ENSDART00000073865.5
      Conserved Domains (4) summary
      pfam01857
      Location:771 → 932
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:386 → 579
      RB_A; Retinoblastoma-associated protein A domain
      pfam08934
      Location:951 → 1041
      Rb_C; Rb C-terminal domain
      pfam11934
      Location:79 → 210
      DUF3452; Domain of unknown function (DUF3452)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      51548575..51573984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476946.2 → XP_021332621.1  retinoblastoma-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QAH9
      Conserved Domains (4) summary
      pfam01857
      Location:771 → 924
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:386 → 579
      RB_A; Retinoblastoma-associated protein A domain
      pfam08934
      Location:943 → 1033
      Rb_C; Rb C-terminal domain
      pfam11934
      Location:79 → 210
      DUF3452; Domain of unknown function (DUF3452)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous