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    CRACDL CRACD like [ Homo sapiens (human) ]

    Gene ID: 343990, updated on 17-Sep-2024

    Summary

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    Official Symbol
    CRACDLprovided by HGNC
    Official Full Name
    CRACD likeprovided by HGNC
    Primary source
    HGNC:HGNC:33454
    See related
    Ensembl:ENSG00000196872 AllianceGenome:HGNC:33454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2orf55; KIAA1211L
    Expression
    Broad expression in brain (RPKM 4.1), esophagus (RPKM 1.2) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CRACDL in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (98793846..98936225, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99252281..99394756, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99410309..99552688, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99386702-99387202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99387203-99387703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99389840-99390340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99390341-99390841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99391147-99392024 Neighboring gene long intergenic non-protein coding RNA 2611 Neighboring gene NANOG hESC enhancer GRCh37_chr2:99395023-99395587 Neighboring gene RNA, U4 small nuclear 84, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14605 Neighboring gene RNA, U7 small nuclear 46 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99485973-99486580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99526123-99526622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99529037-99529620 Neighboring gene Sharpr-MPRA regulatory region 6151 Neighboring gene MPRA-validated peak3796 silencer Neighboring gene testis specific 10 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:99656987-99658186 Neighboring gene NANOG hESC enhancer GRCh37_chr2:99698262-99699020 Neighboring gene SMC3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99758101-99758907 Neighboring gene chromosome 2 open reading frame 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent. Alblooshi H, et al. BMC Psychiatry, 2020 Jan 31. PMID 32005204, Free PMC Article
    2. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Scott LJ, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19416921, Free PMC Article
    3. Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR. Yu C, et al. J Cell Mol Med, 2023 Jun. PMID 37132043, Free PMC Article
    4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, et al. Mol Cell, 2019 Feb 21. PMID 30639242, Free PMC Article
    5. The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei. Nassa G, et al. Sci Data, 2019 Sep 16. PMID 31527615, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.
      Title: Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC42367

    General protein information

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    Preferred Names
    CRACD-like protein
    Names
    KIAA1211 like
    uncharacterized protein C2orf55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207362.3 → NP_997245.2  CRACD-like protein

      See identical proteins and their annotated locations for NP_997245.2

      Status: VALIDATED

      Source sequence(s)
      AC084377, BC068277, BM922097, CF593294
      Consensus CDS
      CCDS42720.1
      UniProtKB/Swiss-Prot
      Q6NV74
      Related
      ENSP00000380996.2, ENST00000397899.7
      Conserved Domains (1) summary
      pfam15262
      Location:145 → 239
      DUF4592; Domain of unknown function (DUF4592)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      98793846..98936225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263926.4 → XP_005263983.1  CRACD-like protein isoform X4

      See identical proteins and their annotated locations for XP_005263983.1

      Conserved Domains (1) summary
      pfam15262
      Location:145 → 239
      DUF4592; Domain of unknown function (DUF4592)

    2. XM_017003972.2 → XP_016859461.1  CRACD-like protein isoform X3

      Conserved Domains (2) summary
      PRK07003
      Location:538 → 840
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15262
      Location:159 → 253
      DUF4592; Domain of unknown function (DUF4592)

    3. XM_011511094.2 → XP_011509396.1  CRACD-like protein isoform X4

      See identical proteins and their annotated locations for XP_011509396.1

      Conserved Domains (1) summary
      pfam15262
      Location:145 → 239
      DUF4592; Domain of unknown function (DUF4592)

    4. XM_011511093.2 → XP_011509395.1  CRACD-like protein isoform X3

      Conserved Domains (2) summary
      PRK07003
      Location:538 → 840
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15262
      Location:159 → 253
      DUF4592; Domain of unknown function (DUF4592)

    5. XM_017003971.2 → XP_016859460.1  CRACD-like protein isoform X3

      Conserved Domains (2) summary
      PRK07003
      Location:538 → 840
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15262
      Location:159 → 253
      DUF4592; Domain of unknown function (DUF4592)

    6. XM_011511095.2 → XP_011509397.1  CRACD-like protein isoform X4

      See identical proteins and their annotated locations for XP_011509397.1

      Conserved Domains (1) summary
      pfam15262
      Location:145 → 239
      DUF4592; Domain of unknown function (DUF4592)

    7. XM_005263924.4 → XP_005263981.1  CRACD-like protein isoform X2

      Conserved Domains (1) summary
      pfam15262
      Location:173 → 267
      DUF4592; Domain of unknown function (DUF4592)

    8. XM_005263923.4 → XP_005263980.1  CRACD-like protein isoform X1

      Conserved Domains (1) summary
      pfam15262
      Location:173 → 267
      DUF4592; Domain of unknown function (DUF4592)

    9. XM_011511096.1 → XP_011509398.1  CRACD-like protein isoform X5

      Conserved Domains (1) summary
      pfam15262
      Location:12 → 106
      DUF4592; Domain of unknown function (DUF4592)

    10. XM_047444123.1 → XP_047300079.1  CRACD-like protein isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      99252281..99394756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341737.1 → XP_054197712.1  CRACD-like protein isoform X4

    2. XM_054341733.1 → XP_054197708.1  CRACD-like protein isoform X3

    3. XM_054341736.1 → XP_054197711.1  CRACD-like protein isoform X4

    4. XM_054341734.1 → XP_054197709.1  CRACD-like protein isoform X3

    5. XM_054341735.1 → XP_054197710.1  CRACD-like protein isoform X3

    6. XM_054341738.1 → XP_054197713.1  CRACD-like protein isoform X4

    7. XM_054341732.1 → XP_054197707.1  CRACD-like protein isoform X2

    8. XM_054341731.1 → XP_054197706.1  CRACD-like protein isoform X1

    9. XM_054341739.1 → XP_054197714.1  CRACD-like protein isoform X5

    10. XM_054341740.1 → XP_054197715.1  CRACD-like protein isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NV74.3 GenPept UniProtKB/Swiss-Prot:Q6NV74

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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