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    RFPL3 ret finger protein like 3 [ Homo sapiens (human) ]

    Gene ID: 10738, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RFPL3provided by HGNC
    Official Full Name
    ret finger protein like 3provided by HGNC
    Primary source
    HGNC:HGNC:9980
    See related
    Ensembl:ENSG00000128276 MIM:605970; AllianceGenome:HGNC:9980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF120
    Summary
    Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of autophagy; positive regulation of canonical NF-kappaB signal transduction; and regulation of viral entry into host cell. Predicted to be located in nucleus. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 12.5) and prostate (RPKM 0.7) See more
    Orthologs
    all
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    Genomic context

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    See RFPL3 in Genome Data Viewer
    Location:
    22q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (32354885..32361161)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (32818820..32825092)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (32750872..32757148)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SLC5A4 antisense RNA 1 Neighboring gene solute carrier family 5 member 4 Neighboring gene CPSF1 pseudogene 1 Neighboring gene uncharacterized LOC107985561 Neighboring gene RFPL3 antisense Neighboring gene immunoglobulin lambda constant/OR22-2 (pseudogene) Neighboring gene uncharacterized LOC339666 Neighboring gene RGL4 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of RFPL3 protein as a novel E3 ubiquitin ligase modulating the integration activity of human immunodeficiency virus, type 1 preintegration complex using a microtiter plate-based assay. Tan BH, et al. J Biol Chem, 2014 Sep 19. PMID 25107902, Free PMC Article
    2. Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. Zohud BA, et al. Cell Death Dis, 2020 Oct 20. PMID 33082305, Free PMC Article
    3. Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. Bonnefont J, et al. Am J Hum Genet, 2008 Aug. PMID 18656177, Free PMC Article
    4. EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells. Lin C, et al. Oncol Rep, 2018 Jul. PMID 29749533, Free PMC Article
    5. Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells. Chen W, et al. Oncotarget, 2014 Dec 15. PMID 25481043, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
      Title: Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
    2. EGF significantly upregulated RFPL3 and hTERT protein levels in the nonsmall cell lung cancer cells. RFPL3 and hTERT proteins upregulation by EGF were attenuated by pretreatment with AG1478 and erlotinib. EGF promoted proliferation and inhibited apoptosis; PD98059 decreased RFPL3 and hTERT protein expression; and RFPL3 overexpression increased the expression of hTERT and related MEKpathway proteins
      Title: EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells.
    3. RFPL3 and CBP have roles in upregulating hTERT activity and promoting lung cancer growth
      Title: RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth.
    4. These results demonstrate that RFPL3 is an important cellular factor which promotes lung cancer growth by activating hTERT expression
      Title: Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells.
    5. RFPL3 is a potential stimulator of human immunodeficiency virus, type 1 (HIV-1) preintegration complex integration.
      Title: Identification of RFPL3 protein as a novel E3 ubiquitin ligase modulating the integration activity of human immunodeficiency virus, type 1 preintegration complex using a microtiter plate-based assay.
    6. the human RFPL1,2,3 genes have a role in neocortex development
      Title: Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol RFPL3 enhances the preintegration complex (PIC) integration activity in vitro, suggesting that HIV-1 IN interacts with RFPL3 in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ret finger protein-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098535.1 → NP_001092005.1  ret finger protein-like 3 isoform 1

      See identical proteins and their annotated locations for NP_001092005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL021937, CR456564
      Consensus CDS
      CCDS43011.1
      UniProtKB/Swiss-Prot
      A2A279, O75679, Q6IC03, Q6IC04, Q6NSX3, Q8N5R4
      UniProtKB/TrEMBL
      Q6NSX6
      Related
      ENSP00000249007.4, ENST00000249007.4
      Conserved Domains (3) summary
      pfam11002
      Location:83 → 124
      RDM; RFPL defining motif (RDM)
      pfam15227
      Location:40 → 81
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15821
      Location:122 → 299
      SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

    2. NM_006604.2 → NP_006595.1  ret finger protein-like 3 isoform 2

      See identical proteins and their annotated locations for NP_006595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and differs in the 5' UTR, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL021937, BC031689
      Consensus CDS
      CCDS13904.1
      UniProtKB/TrEMBL
      Q6NSX6
      Related
      ENSP00000380609.1, ENST00000397468.5
      Conserved Domains (3) summary
      pfam11002
      Location:54 → 95
      RDM; RFPL defining motif (RDM)
      pfam15227
      Location:11 → 52
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15821
      Location:93 → 270
      SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      32354885..32361161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      32818820..32825092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75679.2 GenPept UniProtKB/Swiss-Prot:O75679

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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