SLCO1B7 solute carrier organic anion transporter family member 1B7 (putative) [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLCO1B7provided by HGNC
Official Full Name: solute carrier organic anion transporter family member 1B7 (putative)provided by HGNC
Primary source: HGNC:HGNC:32934
See related: MIM:619875; AllianceGenome:HGNC:32934
Gene type: pseudo
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LST3; LST-3; OATP1B7; SLC21A21; LST-3TM12
Summary: Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 12p12.2

Annotation release	Status	Assembly	Chr	Location
109.20210226	latest, but not current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (21015696..21090106)

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
Title: circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
Title: Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7.
Results showed that OATP1B3-1B7 interacts with several drugs. One of the identified inhibitors was ezetimibe, which is also a substrate ofOATP1B3-1B7. Moreover, ezetimibe glucuronidation rates were decreased by bromsulphthalein, which is a OATP1B3-1B7 inhibitor. Thus, OATP1B3- 1B7 may function as a smooth endoplasmic reticulum gateway for ezetimibe.
Title: OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe.
This study investigated the expression and function of LST-3TM12 as a member of a multigene family.
Title: LST-3TM12 is a member of the OATP1B family and a functional transporter.
Observational study of gene-disease association. (HuGE Navigator)
Title: Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

Genotypes

See SNP Geneview Report

General gene information

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Markers

D12S1836 (e-PCR)
- UniSTS:68175

SLC21A8_826 (e-PCR)
- UniSTS:277731

RH68705 (e-PCR)
- UniSTS:60656

Potential readthrough

Included gene: SLCO1B3

Potential readthrough

Included gene: SLCO1B1

Readthrough SLCO1B3-SLCO1B7

Readthrough gene: SLCO1B3-SLCO1B7, Included gene: SLCO1B3

Homology

NCBI Orthologs

Other Names

liver-specific organic anion transporter 3
liver-specific organic anion transporter 3TM12
organic anion transporter LST-3b
putative solute carrier organic anion transporter family member 1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001009562.4: Suppressed sequence

Description

NM_001009562.4: This RefSeq was removed because it is now thought that this gene does not encode a protein.