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    Trim45 tripartite motif-containing 45 [ Mus musculus (house mouse) ]

    Gene ID: 229644, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trim45provided by MGI
    Official Full Name
    tripartite motif-containing 45provided by MGI
    Primary source
    MGI:MGI:1918187
    See related
    Ensembl:ENSMUSG00000033233 AllianceGenome:MGI:1918187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921530N01Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within bone development. Predicted to be located in cytosol and intercellular bridge. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including axial skeleton; central nervous system; genitourinary system; and sensory organ. Orthologous to human TRIM45 (tripartite motif containing 45). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 4.9), subcutaneous fat pad adult (RPKM 3.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim45 in Genome Data Viewer
    Location:
    3 F2.2; 3 43.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100828516..100844241)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100921203..100936925)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32720 Neighboring gene V-set domain containing T cell activation inhibitor 1 Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene predicted gene, 40108 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene CD101 antigen

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy. Huang X, et al. J Neuroinflammation, 2023 Nov 30. PMID 38037161, Free PMC Article
    2. TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury. Xia Q, et al. Exp Mol Med, 2022 Feb. PMID 35217833, Free PMC Article
    3. E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Zhang J, et al. Cell Death Differ, 2023 Apr. PMID 36681779, Free PMC Article
    4. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Bassett JH, et al. PLoS Genet, 2012. PMID 22876197, Free PMC Article
    5. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.
      Title: TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.
    2. TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury.
      Title: TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM45
    Names
    RING finger protein 99
    tripartite motif-containing protein 45
    NP_001159424.1
    NP_001159425.1
    NP_919324.2
    XP_011238402.1
    XP_030108447.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165952.1 → NP_001159424.1  E3 ubiquitin-protein ligase TRIM45 isoform b

      See identical proteins and their annotated locations for NP_001159424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK150574, AL669872, BY518289
      Consensus CDS
      CCDS17678.1
      UniProtKB/Swiss-Prot
      E9Q2K9, Q3U5H4, Q6PFY8, Q8BVT5
      UniProtKB/TrEMBL
      A2ACL2
      Related
      ENSMUSP00000102593.3, ENSMUST00000106980.9
      Conserved Domains (4) summary
      smart00557
      Location:399 → 497
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00021
      Location:189 → 226
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam00630
      Location:397 → 493
      Filamin; Filamin/ABP280 repeat
      cl23765
      Location:237 → 357
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_001165953.1 → NP_001159425.1  E3 ubiquitin-protein ligase TRIM45 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK076600, AK150574, AL669872, BC057358
      Consensus CDS
      CCDS51018.1
      UniProtKB/Swiss-Prot
      Q6PFY8
      Related
      ENSMUSP00000115669.3, ENSMUST00000134993.3
      Conserved Domains (4) summary
      smart00557
      Location:399 → 497
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00021
      Location:189 → 226
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam00630
      Location:397 → 493
      Filamin; Filamin/ABP280 repeat
      cl23765
      Location:237 → 357
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_194343.2 → NP_919324.2  E3 ubiquitin-protein ligase TRIM45 isoform b

      See identical proteins and their annotated locations for NP_919324.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK150574, BC057358
      Consensus CDS
      CCDS17678.1
      UniProtKB/Swiss-Prot
      E9Q2K9, Q3U5H4, Q6PFY8, Q8BVT5
      UniProtKB/TrEMBL
      A2ACL2
      Related
      ENSMUSP00000043389.7, ENSMUST00000037409.13
      Conserved Domains (4) summary
      smart00557
      Location:399 → 497
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00021
      Location:189 → 226
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam00630
      Location:397 → 493
      Filamin; Filamin/ABP280 repeat
      cl23765
      Location:237 → 357
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      100828516..100844241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240100.3 → XP_011238402.1  E3 ubiquitin-protein ligase TRIM45 isoform X1

      Conserved Domains (3) summary
      smart00502
      Location:65 → 185
      BBC; B-Box C-terminal domain
      pfam00630
      Location:225 → 320
      Filamin; Filamin/ABP280 repeat
      cd19785
      Location:16 → 58
      Bbox2_TRIM45_C-X; B-box-type 2 zinc finger found in tripartite motif-containing protein 45 (TRIM45) and similar proteins

    2. XM_030252587.2 → XP_030108447.1  E3 ubiquitin-protein ligase TRIM45 isoform X2

      Conserved Domains (3) summary
      smart00502
      Location:65 → 185
      BBC; B-Box C-terminal domain
      smart00557
      Location:227 → 325
      IG_FLMN; Filamin-type immunoglobulin domains
      cd19785
      Location:16 → 58
      Bbox2_TRIM45_C-X; B-box-type 2 zinc finger found in tripartite motif-containing protein 45 (TRIM45) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFY8.2 GenPept UniProtKB/Swiss-Prot:Q6PFY8

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