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    LINC00319 long intergenic non-protein coding RNA 319 [ Homo sapiens (human) ]

    Gene ID: 284836, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LINC00319provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 319provided by HGNC
    Primary source
    HGNC:HGNC:19730
    See related
    Ensembl:ENSG00000188660 AllianceGenome:HGNC:19730
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRED49; C21orf125; NCRNA00319
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00319 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43446601..43453902)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41801865..41809166)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44866481..44873782)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44834223-44834804 Neighboring gene uncharacterized LOC124905029 Neighboring gene Sharpr-MPRA regulatory region 10850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44853691-44854192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44854193-44854692 Neighboring gene SIK1-LINC00319 intergenic CAGE-defined high expression enhancer Neighboring gene salt inducible kinase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44865413-44866032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44866033-44866652 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:44867273-44867892 Neighboring gene uncharacterized LOC124900467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44874448-44875423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44875523-44876522 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:44876822-44877032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44882521-44883518 Neighboring gene uncharacterized LOC102723380 Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene long intergenic non-protein coding RNA 313 Neighboring gene Sharpr-MPRA regulatory region 2841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44905292-44906122 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:44908716-44908853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44912277-44913132 Neighboring gene Sharpr-MPRA regulatory region 13752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44918667-44919571 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44922889-44923698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44923814-44924426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44924427-44925037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44928045-44928546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44931227-44931922 Neighboring gene ribosomal protein L31 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00319: Unraveling the spectrum from gene regulation to clinical applications in cancer progression. Su X, et al. Gene, 2024 Feb 20. PMID 38042213
    2. LINC00319 promotes osteosarcoma progression by regulating the miR-455-3p/NFIB axis. Sun F, et al. J Gene Med, 2020 Nov. PMID 32621625
    3. LINC00319 acts as a microRNA-335-5p sponge to accelerate tumor growth and metastasis in gastric cancer by upregulating ADCY3. Zou J, et al. Am J Physiol Gastrointest Liver Physiol, 2020 Jan 1. PMID 31433213
    4. LncRNA LINC00319 is associated with tumorigenesis and poor prognosis in glioma. Li Q, et al. Eur J Pharmacol, 2019 Oct 15. PMID 31325436
    5. Upregulation of LINC00319 indicates a poor prognosis and promotes cell proliferation and invasion in cutaneous squamous cell carcinoma. Li F, et al. J Cell Biochem, 2018 Dec. PMID 30145798

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00319: Unraveling the spectrum from gene regulation to clinical applications in cancer progression.
      Title: LINC00319: Unraveling the spectrum from gene regulation to clinical applications in cancer progression.
    2. LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3.
      Title: LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3.
    3. LINC00319 promotes osteosarcoma progression by regulating the miR-455-3p/NFIB axis.
      Title: LINC00319 promotes osteosarcoma progression by regulating the miR-455-3p/NFIB axis.
    4. Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
      Title: Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
    5. LINC00319 expedited growth and metastasis of gastric cancer by upregulating miR-335-5p-mediated ADCY3 expression.
      Title: LINC00319 acts as a microRNA-335-5p sponge to accelerate tumor growth and metastasis in gastric cancer by upregulating ADCY3.
    6. function role and underlying mechanism of LINC00319 in glioma
      Title: LncRNA LINC00319 is associated with tumorigenesis and poor prognosis in glioma.
    7. LINC00319 is highly expressed in cutaneous squamous cell carcinoma tissues and increased expression of LINC00319 implies a potential link with poor prognosis in cutaneous squamous cell carcinoma patients. LINC00319 exerts its oncogenic functions in cutaneous squamous cell carcinoma through miR-1207-5p-mediated regulation of CDK3.
      Title: Upregulation of LINC00319 indicates a poor prognosis and promotes cell proliferation and invasion in cutaneous squamous cell carcinoma.
    8. LINC00319 promotes ovarian cancer progression through upregulating NACC1 expression by restraining miR-423-5p.
      Title: LncRNA LINC00319 accelerates ovarian cancer progression through miR-423-5p/NACC1 pathway.
    9. Data show that LINC00319 expression is up-regulated in nasopharyngeal carcinoma (NPC) tissues and cells, and its overexpression is associated with poor prognosis. Its knockdown exerts tumor-suppressive role by repressing NPC cell proliferation and tumor growth. Furthermore, LINC00319 functions through functioning as a ceRNA for miR-1207, releasing the miR-1207 inhibitory role for its target gene KLF12.
      Title: Long non-coding RNA 319 facilitates nasopharyngeal carcinoma carcinogenesis through regulation of miR-1207-5p/KLF12 axis.
    10. Confirmation of an oncogenic role for LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR-450b-5p/EZH2 pathway in lung adenocarcinoma tumorigenesis.
      Title: Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Clone Names

    • FLJ38036

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_152722.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001047
      Related
      ENST00000448049.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      43446601..43453902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      41801865..41809166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194309.1: Suppressed sequence

      Description
      NM_194309.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    2. NR_026960.1: Suppressed sequence

      Description
      NR_026960.1: This RefSeq has been removed because currently there is insufficient support for this splice structure.
    Nucleotide Protein
    Heading Accession and Version

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