These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
-
NM_001113511.2 → NP_001106983.1  rho guanine nucleotide exchange factor 7 isoform c
See identical proteins and their annotated locations for NP_001106983.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) represents the longest transcript and encodes isoform c.
- Source sequence(s)
-
AB177848, AK093326, AL353704, BC060776, BM677392, DB180957
- Consensus CDS
-
CCDS45068.1
- UniProtKB/Swiss-Prot
- B1ALK6, B1ALK8, Q14155, Q3LIA4, Q5W9H0, Q6P9G3, Q6PII2, Q86W63, Q8N3M1
- UniProtKB/TrEMBL
-
A0A2X0SF98
- Related
- ENSP00000364893.2, ENST00000375741.6
- Conserved Domains (7) summary
-
- cd12061
Location:188 → 241
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:272 → 449
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:480 → 578
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:634 → 732
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:138 → 184
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
- cl00030
Location:21 → 128
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cl26464
Location:583 → 664
- Atrophin-1; Atrophin-1 family
-
NM_001113512.2 → NP_001106984.1  rho guanine nucleotide exchange factor 7 isoform d
See identical proteins and their annotated locations for NP_001106984.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting protein (isoform d) is shorter than isoform c.
- Source sequence(s)
-
AB177848, AK093326, AL353704, BC033905, BC060776, BM677392, DB180957
- Consensus CDS
-
CCDS45069.1
- UniProtKB/TrEMBL
-
A0A2X0SF98
- Related
- ENSP00000364891.2, ENST00000375739.6
- Conserved Domains (7) summary
-
- cd12061
Location:138 → 191
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- smart00033
Location:21 → 75
- CH; Calponin homology domain
- cd00160
Location:222 → 399
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:430 → 528
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:448 → 528
- PH; PH domain
- pfam16614
Location:584 → 682
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:88 → 134
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
-
NM_001113513.2 → NP_001106985.1  rho guanine nucleotide exchange factor 7 isoform a
See identical proteins and their annotated locations for NP_001106985.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
- Source sequence(s)
-
AL390754, BC050521, CF121796, CF144155, D63476, DA216264
- Consensus CDS
-
CCDS9521.1
- Related
- ENSP00000397068.2, ENST00000426073.6
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:557 → 643
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001320851.2 → NP_001307780.1  rho guanine nucleotide exchange factor 7 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
- Source sequence(s)
-
AB177849, AL390754, BC050521, CF121796, CF144155, D63476, DA404477
- Consensus CDS
-
CCDS9521.1
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:557 → 643
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001320852.1 → NP_001307781.1  rho guanine nucleotide exchange factor 7 isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) lacks an in-frame exon in the 5' coding region and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (e) lacks a portion of the N-terminus and has a longer, distinct C-terminus, compared to isoform c.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS91837.1
- UniProtKB/TrEMBL
- A0A2X0SF98, A0A8V8TQ72
- Related
- ENSP00000514984.1, ENST00000700426.1
- Conserved Domains (8) summary
-
- cd12061
Location:167 → 220
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00014
Location:21 → 107
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00160
Location:251 → 428
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:459 → 557
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:477 → 557
- PH; PH domain
- pfam16523
Location:714 → 800
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:613 → 711
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:117 → 163
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
-
NM_001320853.2 → NP_001307782.1  rho guanine nucleotide exchange factor 7 isoform f
Status: REVIEWED
- Description
- Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (f) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
- Source sequence(s)
-
AK300272, BC050521, CF121796, CF144155
- UniProtKB/TrEMBL
- B7Z6G2, Q5W9H1
- Conserved Domains (7) summary
-
- cd12061
Location:85 → 138
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:169 → 346
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:377 → 475
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:395 → 475
- PH; PH domain
- pfam16523
Location:632 → 718
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:531 → 629
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:35 → 81
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
-
NM_001320854.2 → NP_001307783.1  rho guanine nucleotide exchange factor 7 isoform g
Status: REVIEWED
- Description
- Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (g) has a distinct, shorter N-terminus, compared to isoform c.
- Source sequence(s)
-
AK093326, AK295472, AK308897, BC060776, BM677392, DB180957
- Consensus CDS
-
CCDS81781.1
- UniProtKB/TrEMBL
- B7Z344, E9PDQ5
- Related
- ENSP00000417596.1, ENST00000478679.5
- Conserved Domains (4) summary
-
- cd00160
Location:16 → 193
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:224 → 322
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:242 → 322
- PH; PH domain
- pfam16614
Location:378 → 476
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
-
NM_001330597.2 → NP_001317526.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
- Source sequence(s)
-
AB075521, AL139086, AL390754, AW872844, BC060776, D63476, DA404477
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001330598.2 → NP_001317527.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. It initiates translation at a downstream start codon. The resulting protein (isoform h) has a shorter N-terminus than isoform c. Variants 10, 11, and 22-26 all encode the same isoform (h).
- Source sequence(s)
-
AB075521, AB177849, AL139086, AL390754, AW872844, BC060776, D63476, DA404477
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354046.2 → NP_001340975.1  rho guanine nucleotide exchange factor 7 isoform i
Status: REVIEWED
- Description
- Transcript Variant: This variant (12) encodes the longest isoform (i).
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86360.1
- UniProtKB/TrEMBL
- A0A2R8YG42, A0A2X0SF98
- Related
- ENSP00000495631.1, ENST00000646102.2
- Conserved Domains (8) summary
-
- cd12061
Location:167 → 220
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00014
Location:21 → 107
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00160
Location:251 → 428
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:459 → 557
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:773 → 859
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:613 → 711
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:117 → 163
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
- cl26464
Location:562 → 643
- Atrophin-1; Atrophin-1 family
-
NM_001354047.1 → NP_001340976.1  rho guanine nucleotide exchange factor 7 isoform j
Status: REVIEWED
- Source sequence(s)
-
AL139086, AL353704, AL390754
- UniProtKB/TrEMBL
-
A0A2X0SF98
- Conserved Domains (6) summary
-
- cd12061
Location:95 → 148
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- smart00033
Location:21 → 96
- CH; Calponin homology domain
- cd00160
Location:179 → 356
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:387 → 485
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:541 → 639
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:490 → 571
- Atrophin-1; Atrophin-1 family
-
NM_001354048.1 → NP_001340977.1  rho guanine nucleotide exchange factor 7 isoform k
Status: REVIEWED
- Description
- Transcript Variant: This variant (14), as well as variants 15-17, encodes isoform k.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86361.1
- UniProtKB/TrEMBL
-
B1ALK7
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:616 → 702
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354049.2 → NP_001340978.1  rho guanine nucleotide exchange factor 7 isoform k
Status: REVIEWED
- Description
- Transcript Variant: This variant (15), as well as variants 14, 16, and 17, encodes isoform k.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86361.1
- UniProtKB/TrEMBL
-
B1ALK7
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:616 → 702
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354050.2 → NP_001340979.1  rho guanine nucleotide exchange factor 7 isoform k
Status: REVIEWED
- Description
- Transcript Variant: This variant (16), as well as variants 14, 15, and 17, encodes isoform k.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86361.1
- UniProtKB/TrEMBL
-
B1ALK7
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:616 → 702
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354051.2 → NP_001340980.1  rho guanine nucleotide exchange factor 7 isoform k
Status: REVIEWED
- Description
- Transcript Variant: This variant (17), as well as variants 14-16, encodes isoform k.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86361.1
- UniProtKB/TrEMBL
-
B1ALK7
- Related
- ENSP00000218789.5, ENST00000218789.9
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:616 → 702
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354052.2 → NP_001340981.1  rho guanine nucleotide exchange factor 7 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (18), as well as variants 1, 5, 6, and 19, encodes isoform a.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS9521.1
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:557 → 643
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354053.2 → NP_001340982.1  rho guanine nucleotide exchange factor 7 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (19), as well as variants 1, 5, 6, and 18, encodes isoform a.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS9521.1
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:557 → 643
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354054.2 → NP_001340983.1  rho guanine nucleotide exchange factor 7 isoform l
Status: REVIEWED
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:569 → 655
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 566
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:407 → 490
- Atrophin-1; Atrophin-1 family
-
NM_001354055.2 → NP_001340984.1  rho guanine nucleotide exchange factor 7 isoform m
Status: REVIEWED
- Source sequence(s)
-
AL139086
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd00160
Location:16 → 193
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:224 → 322
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:538 → 624
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:378 → 476
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:327 → 408
- Atrophin-1; Atrophin-1 family
-
NM_001354056.1 → NP_001340985.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (22), as well as variants 10, 11, and 23-26, encodes isoform h.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354057.2 → NP_001340986.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (23), as well as variants 10, 11, 22, and 24-26, encodes isoform h.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354058.2 → NP_001340987.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (24), as well as variants 10, 11, 22, 23, 25, and 26, encodes isoform h.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354059.2 → NP_001340988.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (25), as well as variants 10, 11, 22-24, and 26, encodes isoform h.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354060.2 → NP_001340989.1  rho guanine nucleotide exchange factor 7 isoform h
Status: REVIEWED
- Description
- Transcript Variant: This variant (26), as well as variants 10, 11, and 22-25, encodes isoform h.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS86362.1
- UniProtKB/TrEMBL
-
B7Z344
- Related
- ENSP00000364875.1, ENST00000375723.5
- Conserved Domains (5) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_001354061.2 → NP_001340990.1  rho guanine nucleotide exchange factor 7 isoform n
Status: REVIEWED
- Source sequence(s)
-
AL139086
- UniProtKB/TrEMBL
-
B7Z344
- Conserved Domains (4) summary
-
- cd00160
Location:20 → 147
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:178 → 276
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16614
Location:332 → 430
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:283 → 366
- Atrophin-1; Atrophin-1 family
-
NM_003899.5 → NP_003890.1  rho guanine nucleotide exchange factor 7 isoform a
See identical proteins and their annotated locations for NP_003890.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.
- Source sequence(s)
-
AL139086, AL353704, AL390754
- Consensus CDS
-
CCDS9521.1
- Related
- ENSP00000364888.4, ENST00000375736.8
- Conserved Domains (6) summary
-
- cd12061
Location:10 → 63
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00160
Location:94 → 271
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:302 → 400
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam16523
Location:557 → 643
- betaPIX_CC; betaPIX coiled coil
- pfam16614
Location:456 → 554
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- cl26464
Location:405 → 486
- Atrophin-1; Atrophin-1 family
-
NM_145735.3 → NP_663788.1  rho guanine nucleotide exchange factor 7 isoform b
See identical proteins and their annotated locations for NP_663788.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting protein (isoform b) is shorter than isoform c.
- Source sequence(s)
-
AB177848, AK093326, AL353704, AL834228, BC060776, BM677392, DB180957
- Consensus CDS
-
CCDS32009.1
- UniProtKB/TrEMBL
-
A0A2X0SF98
- Related
- ENSP00000325994.5, ENST00000317133.9
- Conserved Domains (7) summary
-
- cd12061
Location:167 → 220
- SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor
- cd00014
Location:21 → 107
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00160
Location:251 → 428
- RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
- cd01225
Location:459 → 557
- PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
- pfam00169
Location:477 → 557
- PH; PH domain
- pfam16614
Location:613 → 711
- RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
- pfam16615
Location:117 → 163
- RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7