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    LRRC10B leucine rich repeat containing 10B [ Homo sapiens (human) ]

    Gene ID: 390205, updated on 17-Sep-2024

    Summary

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    Official Symbol
    LRRC10Bprovided by HGNC
    Official Full Name
    leucine rich repeat containing 10Bprovided by HGNC
    Primary source
    HGNC:HGNC:37215
    See related
    Ensembl:ENSG00000204950 AllianceGenome:HGNC:37215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Orthologs
    mouse all
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    Genomic context

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    See LRRC10B in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61508749..61511018)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61497629..61499898)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61276221..61278490)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369329 Neighboring gene MPRA-validated peak1286 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61280313-61280926 Neighboring gene microRNA 4488 Neighboring gene synaptotagmin 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61297435-61297934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61301414-61302353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61302354-61303292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3396 Neighboring gene uncharacterized LOC105369331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61354237-61354816 Neighboring gene uncharacterized LOC101927495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61355975-61356553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61366831-61367498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61368167-61368834

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma. Chen J, et al. Oncol Rep, 2016 Sep. PMID 27460542
    2. E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis. Guo Y, et al. Mol Immunol, 2020 May. PMID 32298923
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
    4. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
    5. Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Chrustowicz J, et al. Mol Cell, 2024 Jan 18. PMID 38113892,

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRC10B may be a downstream gene regulated by RPLP0P2
      Title: Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 10B
    Names
    LRRC10-like protein ENSP00000367315

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145077.2 → NP_001138549.1  leucine-rich repeat-containing protein 10B

      See identical proteins and their annotated locations for NP_001138549.1

      Status: VALIDATED

      Source sequence(s)
      AP003108, AW137416
      Consensus CDS
      CCDS44621.1
      UniProtKB/Swiss-Prot
      A6NIK2
      Related
      ENSP00000367315.2, ENST00000378075.4
      Conserved Domains (3) summary
      sd00033
      Location:24 → 45
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:90 → 129
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:90 → 148
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      61508749..61511018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      61497629..61499898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NIK2.2 GenPept UniProtKB/Swiss-Prot:A6NIK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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