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    SLC15A2 solute carrier family 15 member 2 [ Homo sapiens (human) ]

    Gene ID: 6565, updated on 28-Oct-2024

    Summary

    Official Symbol
    SLC15A2provided by HGNC
    Official Full Name
    solute carrier family 15 member 2provided by HGNC
    Primary source
    HGNC:HGNC:10921
    See related
    Ensembl:ENSG00000163406 MIM:602339; AllianceGenome:HGNC:10921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PEPT2
    Summary
    The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
    Expression
    Biased expression in prostate (RPKM 19.8), brain (RPKM 10.1) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC15A2 in Genome Data Viewer
    Location:
    3q13.33
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (121894401..121944188)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (124614370..124664153)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (121613248..121663035)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20349 Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:121611674-121612207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:121612208-121612740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:121657363-121657943 Neighboring gene uncharacterized LOC101927010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:121711615-121712116 Neighboring gene Sharpr-MPRA regulatory region 6303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20352 Neighboring gene NANOG hESC enhancer GRCh37_chr3:121724759-121725260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20354 Neighboring gene immunoglobulin like domain containing receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20363 Neighboring gene CD86 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14639

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ33407

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dipeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide:proton symporter activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tripeptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dipeptide import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dipeptide import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dipeptide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidoglycan transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in renal absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in tripeptide import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in xenobiotic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    is_active_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 15 member 2
    Names
    kidney H(+)/peptide cotransporter
    peptide transporter 2
    solute carrier family 15 (H+/peptide transporter), member 2
    solute carrier family 15 (oligopeptide transporter), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145998.2NP_001139470.1  solute carrier family 15 member 2 isoform b

      See identical proteins and their annotated locations for NP_001139470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC072031
      Consensus CDS
      CCDS54631.1
      UniProtKB/TrEMBL
      B4DXJ3
      Related
      ENSP00000295605.2, ENST00000295605.6
      Conserved Domains (2) summary
      TIGR00926
      Location:58665
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
      pfam00854
      Location:114450
      PTR2; POT family
    2. NM_021082.4NP_066568.3  solute carrier family 15 member 2 isoform a

      See identical proteins and their annotated locations for NP_066568.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC072031
      Consensus CDS
      CCDS3007.1
      UniProtKB/Swiss-Prot
      A8K1A5, B4E2A7, Q16348
      UniProtKB/TrEMBL
      Q86UE9
      Related
      ENSP00000417085.1, ENST00000489711.6
      Conserved Domains (1) summary
      TIGR00926
      Location:58696
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      121894401..121944188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247722.4XP_005247779.1  solute carrier family 15 member 2 isoform X1

      UniProtKB/TrEMBL
      Q86UE9
      Conserved Domains (2) summary
      TIGR00926
      Location:58661
      2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
      pfam00854
      Location:111481
      PTR2; POT family
    2. XM_006713736.4XP_006713799.1  solute carrier family 15 member 2 isoform X2

      Conserved Domains (1) summary
      pfam00854
      Location:111481
      PTR2; POT family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      124614370..124664153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347623.1XP_054203598.1  solute carrier family 15 member 2 isoform X1

    2. XM_054347624.1XP_054203599.1  solute carrier family 15 member 2 isoform X2