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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_008209.1 RefSeqGene
- Range
-
5001..151695
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_433
mRNA and Protein(s)
-
NM_001105206.3 → NP_001098676.2 laminin subunit alpha-4 isoform 1 precursor
See identical proteins and their annotated locations for NP_001098676.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AB210027, Z99289
- Consensus CDS
-
CCDS43491.1
- UniProtKB/Swiss-Prot
- Q14731, Q14735, Q15335, Q16363, Q4LE44, Q5SZG8, Q9BTB8, Q9UE18, Q9UJN9
- UniProtKB/TrEMBL
-
A0A0A0MQS9
- Related
- ENSP00000230538.7, ENST00000230538.12
- Conserved Domains (5) summary
-
- COG1196
Location:407 → 752
- Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1492 → 1624
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:298 → 554
- Laminin_I; Laminin Domain I
- pfam06009
Location:734 → 861
- Laminin_II; Laminin Domain II
-
NM_001105207.3 → NP_001098677.2 laminin subunit alpha-4 isoform 2 precursor
See identical proteins and their annotated locations for NP_001098677.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses alternate splice sites in the 5' UTR and 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
- Source sequence(s)
-
AB210027, BC066552, Z99289
- Consensus CDS
-
CCDS34514.1
- UniProtKB/TrEMBL
- A0A0A0MTC7, Q5D044
- Related
- ENSP00000429488.1, ENST00000522006.5
- Conserved Domains (7) summary
-
- COG1340
Location:419 → 717
- COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1485 → 1617
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:289 → 547
- Laminin_I; Laminin Domain I
- pfam06009
Location:727 → 854
- Laminin_II; Laminin Domain II
- cl02488
Location:332 → 524
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cl09111
Location:503 → 602
- Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
-
NM_001105208.3 → NP_001098678.1 laminin subunit alpha-4 isoform 3 precursor
See identical proteins and their annotated locations for NP_001098678.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a protein (isoform 3) with a shorter, distinct C-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (3).
- Source sequence(s)
-
BC004241, BM014298, BP234809
- Consensus CDS
-
CCDS43492.1
- UniProtKB/Swiss-Prot
-
Q16363
- Related
- ENSP00000357627.4, ENST00000368638.5
-
NM_001105209.3 → NP_001098679.1 laminin subunit alpha-4 isoform 3 precursor
See identical proteins and their annotated locations for NP_001098679.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) uses alternate splice sites in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 3) with a shorter, distinct C-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (3).
- Source sequence(s)
-
BC004241, BP234809
- Consensus CDS
-
CCDS43492.1
- UniProtKB/Swiss-Prot
-
Q16363
- Related
- ENSP00000398226.2, ENST00000453937.2
-
NM_002290.5 → NP_002281.3 laminin subunit alpha-4 isoform 2 precursor
See identical proteins and their annotated locations for NP_002281.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
- Source sequence(s)
-
AB210027, X91171, Z99289
- Consensus CDS
-
CCDS34514.1
- UniProtKB/TrEMBL
- A0A0A0MTC7, Q5D044
- Related
- ENSP00000374114.4, ENST00000389463.9
- Conserved Domains (7) summary
-
- COG1340
Location:419 → 717
- COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1485 → 1617
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:289 → 547
- Laminin_I; Laminin Domain I
- pfam06009
Location:727 → 854
- Laminin_II; Laminin Domain II
- cl02488
Location:332 → 524
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cl09111
Location:503 → 602
- Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000006.12 Reference GRCh38.p14 Primary Assembly
- Range
-
112107931..112254985 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047418770.1 → XP_047274726.1 laminin subunit alpha-4 isoform X2
- UniProtKB/TrEMBL
-
A0A0A0MTC7
-
XM_047418769.1 → XP_047274725.1 laminin subunit alpha-4 isoform X1
- UniProtKB/TrEMBL
-
A0A0A0MQS9
- Conserved Domains (5) summary
-
- COG1196
Location:407 → 752
- Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1492 → 1624
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:298 → 554
- Laminin_I; Laminin Domain I
- pfam06009
Location:734 → 861
- Laminin_II; Laminin Domain II
-
XM_017010854.3 → XP_016866343.1 laminin subunit alpha-4 isoform X2
- UniProtKB/TrEMBL
- A0A0A0MTC7, Q5D044
- Conserved Domains (7) summary
-
- COG1340
Location:419 → 717
- COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1485 → 1617
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:289 → 547
- Laminin_I; Laminin Domain I
- pfam06009
Location:727 → 854
- Laminin_II; Laminin Domain II
- cl02488
Location:332 → 524
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- cl09111
Location:503 → 602
- Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
-
XM_005266984.5 → XP_005267041.2 laminin subunit alpha-4 isoform X1
See identical proteins and their annotated locations for XP_005267041.2
- UniProtKB/Swiss-Prot
- Q14731, Q14735, Q15335, Q16363, Q4LE44, Q5SZG8, Q9BTB8, Q9UE18, Q9UJN9
- UniProtKB/TrEMBL
-
A0A0A0MQS9
- Conserved Domains (5) summary
-
- COG1196
Location:407 → 752
- Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1492 → 1624
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:298 → 554
- Laminin_I; Laminin Domain I
- pfam06009
Location:734 → 861
- Laminin_II; Laminin Domain II
-
XM_005266983.5 → XP_005267040.2 laminin subunit alpha-4 isoform X1
See identical proteins and their annotated locations for XP_005267040.2
- UniProtKB/Swiss-Prot
- Q14731, Q14735, Q15335, Q16363, Q4LE44, Q5SZG8, Q9BTB8, Q9UE18, Q9UJN9
- UniProtKB/TrEMBL
-
A0A0A0MQS9
- Conserved Domains (5) summary
-
- COG1196
Location:407 → 752
- Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
- cd00055
Location:187 → 238
- EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
- cd00110
Location:1492 → 1624
- LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
- pfam06008
Location:298 → 554
- Laminin_I; Laminin Domain I
- pfam06009
Location:734 → 861
- Laminin_II; Laminin Domain II
-
XM_047418771.1 → XP_047274727.1 laminin subunit alpha-4 isoform X3
Alternate T2T-CHM13v2.0
Genomic
-
NC_060930.1 Alternate T2T-CHM13v2.0
- Range
-
113291349..113438419 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054355422.1 → XP_054211397.1 laminin subunit alpha-4 isoform X2
-
XM_054355420.1 → XP_054211395.1 laminin subunit alpha-4 isoform X1
-
XM_054355421.1 → XP_054211396.1 laminin subunit alpha-4 isoform X2
-
XM_054355419.1 → XP_054211394.1 laminin subunit alpha-4 isoform X1
-
XM_054355418.1 → XP_054211393.1 laminin subunit alpha-4 isoform X1
-
XM_054355423.1 → XP_054211398.1 laminin subunit alpha-4 isoform X3