PI16 peptidase inhibitor 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PI16provided by HGNC
Official Full Name: peptidase inhibitor 16provided by HGNC
Primary source: HGNC:HGNC:21245
See related: Ensembl:ENSG00000164530 AllianceGenome:HGNC:21245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD364; PSPBP; CRISP9; MSMBBP
Summary: Predicted to enable peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to act upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in urinary bladder (RPKM 35.7), heart (RPKM 28.3) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (36948296..36964837)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (36771401..36787902)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (36916072..36932613)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling.
Title: Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling.
Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
Title: Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
this study shows that Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes
Title: Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes.
this study shows that skin-homing CD8(+) T cells preferentially express GPI-anchored peptidase inhibitor 16
Title: Skin-homing CD8(+) T cells preferentially express GPI-anchored peptidase inhibitor 16, an inhibitor of cathepsin K.
at high endothelial shear stress, PI16 contributes to inhibition of MMP2 protease activity, protection that can be reversed during inflammation
Title: PI16 is a shear stress and inflammation-regulated inhibitor of MMP2.
PI16-positive Treg showed enhanced in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation
Title: PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20.
a novel and independent prognostic markers following radical prostatectomy for prostate cancer.
Title: Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy.
A new blood protein PSP94-binding protein (PSPBP) is identified that binds prostate secretory protein of 94 amino acids (PSP94).
Title: Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Chemerin, a novel adipokine in the regulation of angiogenesis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptidase inhibitor 16

Names: PSP94-binding protein; cysteine-rich secretory protein 9; microseminoprotein, beta-binding protein; protease inhibitor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199159.2 → NP_001186088.1 peptidase inhibitor 16 precursor

See identical proteins and their annotated locations for NP_001186088.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL050088, BC022399, DA342875, DB178215

Consensus CDS

CCDS34440.1

UniProtKB/Swiss-Prot

Q6UXB8, Q6ZVG9, Q8IYL8, Q8NBK0, Q8TCB8

UniProtKB/TrEMBL

B2R701

Related

ENSP00000478888.1, ENST00000611814.4

Conserved Domains (1) summary

cd05559
Location:33 → 166

SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...
NM_153370.3 → NP_699201.2 peptidase inhibitor 16 precursor

See identical proteins and their annotated locations for NP_699201.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL050088, BC022399, BC035634

Consensus CDS

CCDS34440.1

UniProtKB/Swiss-Prot

Q6UXB8, Q6ZVG9, Q8IYL8, Q8NBK0, Q8TCB8

UniProtKB/TrEMBL

B2R701

Related

ENSP00000362778.3, ENST00000373674.4

Conserved Domains (1) summary

cd05559
Location:33 → 166

SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

36948296..36964837

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514375.4 → XP_011512677.1 peptidase inhibitor 16 isoform X1

See identical proteins and their annotated locations for XP_011512677.1

UniProtKB/Swiss-Prot

Q6UXB8, Q6ZVG9, Q8IYL8, Q8NBK0, Q8TCB8

UniProtKB/TrEMBL

B2R701

Conserved Domains (1) summary

cd05559
Location:33 → 166

SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...
XM_017010430.3 → XP_016865919.1 peptidase inhibitor 16 isoform X2

UniProtKB/Swiss-Prot

Q6UXB8

Conserved Domains (1) summary

cl00133
Location:33 → 166

SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
XM_005248917.4 → XP_005248974.1 peptidase inhibitor 16 isoform X2

UniProtKB/Swiss-Prot

Q6UXB8

Conserved Domains (1) summary

cl00133
Location:33 → 166

SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...