CSNK2A2 casein kinase 2 alpha 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CSNK2A2provided by HGNC
Official Full Name: casein kinase 2 alpha 2provided by HGNC
Primary source: HGNC:HGNC:2459
See related: Ensembl:ENSG00000070770 MIM:115442; AllianceGenome:HGNC:2459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CK2A2; CSNK2A1; CK2alpha'
Summary: This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]
Expression: Broad expression in testis (RPKM 55.0), skin (RPKM 19.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (58157907..58198106, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (63953540..63993732, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (58191811..58232010, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein kinase CK2alpha is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapy.
Title: Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapy.
Protein Kinase CK2alpha', More than a Backup of CK2alpha.
Title: Protein Kinase CK2α', More than a Backup of CK2α.
Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2alpha complexes.
Title: Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2α complexes.
CSNK2A2 promotes hepatocellular carcinoma progression through activation of NF-kappaB pathway.
Title: CSNK2A2 promotes hepatocellular carcinoma progression through activation of NF-κB pathway.
CK2alpha causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway.
Title: CK2α causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway.
Casein Kinase 2alpha Augments Oxaliplatin Resistance in Colorectal Cancer Cells by Increasing ABCE1 Expression.
Title: Casein Kinase 2α Augments Oxaliplatin Resistance in Colorectal Cancer Cells by Increasing ABCE1 Expression.
Okur-Chung neurodevelopmental syndrome-linked CK2alpha variants have reduced kinase activity.
Title: Okur-Chung neurodevelopmental syndrome-linked CK2α variants have reduced kinase activity.
Multiple conformations of kinase II subunit alpha (CK2alpha) hinge region, located near the active site, were observed during the dynamics.
Title: Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition.
The influence of the combined treatment on apoptosis in leukemia cells, as well as on cell-cycle progression and the levels of TS, CK2alpha and P-Ser529-p65 were determined.
Title: Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
CK2 is required to mediate FXR SUMOylation.
Title: A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, casein kinase 2 alpha prime polypeptide (CSNK2A2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2A2 is decreased by RRE	PubMed
	rev	CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23	PubMed
	rev	Rev activates CK2, an effect hypothesized to promote HIV-1 replication	PubMed
	rev	phosphorylation of Rev is dependent on the beta subunit of CK2	PubMed
	rev	amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions	PubMed
	rev	CK2 phosphorylates Rev on Serine 5 and Serine 8	PubMed
Vpu	vpu	Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation	PubMed
	vpu	The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56	PubMed
matrix	gag	CK2 has been shown to phosphorylate HIV-1 Matrix in vitro	PubMed
retropepsin	gag-pol	Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation	PubMed
reverse transcriptase	gag-pol	Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells	PubMed
	gag-pol	Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CSNK2A2 (e-PCR)
- UniSTS:253714

RH36293 (e-PCR)
- UniSTS:83762

D16S3208 (e-PCR)
- UniSTS:84

RH98766 (e-PCR)
- UniSTS:84591

D16S3223 (e-PCR)
- UniSTS:29850

D16S3204 (e-PCR)
- UniSTS:32932

SHGC-60810 (e-PCR)
- UniSTS:66778

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IDA Inferred from Direct Assay more info	PubMed
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein targeting to mitochondrion	HMP more info	PubMed
involved_in regulation of chromosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitophagy	HMP more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: casein kinase II subunit alpha'

Names: CK II alpha'; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide

NP_001887.1

EC 2.7.11.1

XP_005255858.1

EC 2.7.11.1

XP_016878434.1

EC 2.7.11.1

XP_047289582.1

EC 2.7.11.1

XP_054235601.1

EC 2.7.11.1

XP_054235602.1

EC 2.7.11.1

XP_054235603.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001896.4 → NP_001887.1 casein kinase II subunit alpha'

See identical proteins and their annotated locations for NP_001887.1

Status: REVIEWED

Source sequence(s)

AC009107

Consensus CDS

CCDS10794.1

UniProtKB/Swiss-Prot

P19784

Related

ENSP00000262506.3, ENST00000262506.8

Conserved Domains (1) summary

cd14132
Location:22 → 326

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

58157907..58198106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047433626.1 → XP_047289582.1 casein kinase II subunit alpha' isoform X1

UniProtKB/Swiss-Prot

P19784
XM_005255801.4 → XP_005255858.1 casein kinase II subunit alpha' isoform X3

See identical proteins and their annotated locations for XP_005255858.1

UniProtKB/TrEMBL

H3BSA1

Conserved Domains (1) summary

cd14132
Location:1 → 189

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_017022945.2 → XP_016878434.1 casein kinase II subunit alpha' isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

63953540..63993732 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054379626.1 → XP_054235601.1 casein kinase II subunit alpha' isoform X1

UniProtKB/Swiss-Prot

P19784
XM_054379628.1 → XP_054235603.1 casein kinase II subunit alpha' isoform X3
XM_054379627.1 → XP_054235602.1 casein kinase II subunit alpha' isoform X2